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[Preprint]. 2021 Sep 17:2021.02.17.21251942.
doi: 10.1101/2021.02.17.21251942.

SARS-CoV-2 Seroprevalence in a University Community: A Longitudinal Study of the Impact of Student Return to Campus on Infection Risk Among Community Members

Callum R K Arnold  1   2 , Sreenidhi Srinivasan  2   3 , Sophie Rodriguez  3 , Natalie Rydzak  4 , Catherine M Herzog  2   3 , Abhinay Gontu  4 , Nita Bharti  1   2 , Meg Small  5   6 , Connie J Rogers  7 , Margeaux M Schade  6 , Suresh V Kuchipudi  2   4 , Vivek Kapur  2   3   8 , Andrew Read  1   2   3 , Matthew J Ferrari  1   2
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SARS-CoV-2 Seroprevalence in a University Community: A Longitudinal Study of the Impact of Student Return to Campus on Infection Risk Among Community Members

Callum R K Arnold et al. medRxiv. .

Update in

Abstract

Background: Returning university students represent large-scale, transient demographic shifts and a potential source of transmission to adjacent communities during the COVID-19 pandemic.

Methods: In this prospective longitudinal cohort study, we tested for IgG antibodies against SARS-CoV-2 in a non-random cohort of residents living in Centre County prior to the Fall 2020 term at the Pennsylvania State University and following the conclusion of the Fall 2020 term. We also report the seroprevalence in a non-random cohort of students collected at the end of the Fall 2020 term.

Results: Of 1313 community participants, 42 (3.2%) were positive for SARS-CoV-2 IgG antibodies at their first visit between 07 August and 02 October 2020. Of 684 student participants who returned to campus for fall instruction, 208 (30.4%) were positive for SARS-CoV-2 antibodies between 26 October and 21 December. 96 (7.3%) community participants returned a positive IgG antibody result by 19 February. Only contact with known SARS-CoV-2-positive individuals and attendance at small gatherings (20-50 individuals) were significant predictors of detecting IgG antibodies among returning students (aOR, 95% CI: 3.1, 2.07-4.64; 1.52, 1.03-2.24; respectively).

Conclusions: Despite high seroprevalence observed within the student population, seroprevalence in a longitudinal cohort of community residents was low and stable from before student arrival for the Fall 2020 term to after student departure. The study implies that heterogeneity in SARS-CoV-2 transmission can occur in geographically coincident populations.

Keywords: COVID-19; SARS-CoV-2; Seroprevalence.

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Conflict of interest statement

Conflicts of Interest and Financial Disclosures The authors declare no conflicts of interest.

Figures

Figure 1:
Figure 1:
Map of Centre County, Pennsylvania, USA. Blue indicates the 5 townships and 1 borough that comprise the Centre Region. Red indicates the location of The Pennsylvania State University (PSU), University Park (UP) Campus. Inset illustrates the proportion of the county population in each region; PSU indicates the estimated student population that returned to campus for the Fall 2020 term.
Figure 2:
Figure 2:
Raw seroprevalence (circles) with 95% binomial confidence intervals for the community residents at the first visit at the start of the Fall 2020 term (light blue), returning students at the end of the fall 2020 term (red), and community residents at either the first or the second visit after student departure (dark blue).
Figure 3:
Figure 3:
Estimated true prevalence (circles, with 95% confidence intervals) among participants at each sampling interval corrected for estimated assay sensitivity as a function of the assumed assay specificity (x-axis). Light blue indicates community residents at the first visit at the start of the Fall 2020 term, red indicates returning students at the end of the Fall 2020 term, and dark blue indicates community residents at the second visit after student departure.
See this image and copyright information in PMC

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