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. 2021 Jan;62(1):34-38.
doi: 10.11622/smedj.2019155. Epub 2019 Dec 2.

Preventing early-onset group B streptococcal sepsis: clinical risk factor-based screening or culture-based screening?

Jiun Lee  1 , Krishnamoorthy Naiduvaje  1 , Ka Lip Chew  2 , Natasha Charan  1 , Yiong Huak Chan  3 , Raymond Tzer-Pin Lin  4 , Eu Leong Yong  5
Affiliations

Preventing early-onset group B streptococcal sepsis: clinical risk factor-based screening or culture-based screening?

Jiun Lee et al. Singapore Med J. 2021 Jan.

Abstract

Introduction: Two strategies are available for prevention of early-onset group B streptococcal (GBS) sepsis - clinical risk factor-based screening and routine culture-based screening of pregnant women for GBS colonisation. In our hospital, we switched from the former to the latter approach in 2014.

Methods: We compared the incidence of early-onset GBS sepsis during 2001-2015 between infants born to pregnant women who were screened for GBS colonisation and those born to women who were not screened.

Results: Among 41,143 live births, there were nine cases of early-onset GBS sepsis. All infants with GBS sepsis were born to pregnant women who were not screened for GBS colonisation. The incidence of early-onset GBS sepsis among infants of women who were not screened was 0.41 per 1,000 live births (95% confidence interval [CI] 0.19-0.77) when compared to infants of women who were screened, for whom the sepsis incidence was zero per 1,000 live births (95% CI 0-0.19; p = 0.005).

Conclusion: Our data suggests that routine culture-based screening of pregnant women for GBS colonisation is a better preventive strategy for early-onset GBS sepsis in neonates when compared to clinical risk factor-based screening.

Keywords: group B streptococcal; neonatal; prevention; screening.

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