Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 May;34(3):e14907.
doi: 10.1111/dth.14907. Epub 2021 Mar 2.

Parotid metastases of cutaneous squamous cell carcinoma in renal transplant recipients: Case series and literature review

Mislav Mokos  1 , Nikolina Bašić-Jukić  1
Affiliations
Review

Parotid metastases of cutaneous squamous cell carcinoma in renal transplant recipients: Case series and literature review

Mislav Mokos et al. Dermatol Ther. 2021 May.

Abstract

Cutaneous squamous cell skin carcinoma (cSCC) is the most common skin cancer in renal transplant recipients (RTR). Metastatic potential of cSCC is significantly higher in RTR than in the general population. Parotid metastases (PM) of cSCC are rare, but their prognosis is poor. The present study aimed to investigate the frequency and characteristics of PM of cSCC in our renal transplant cohort. Among 1610 patients who received kidney allografts at our institution in the period from January 1999 to December 2019, 84 patients (5.2%) developed at least one cSCC. Three patients were identified to develop PM within 3 to 6 months after the occurrence of primary cSCC. All PM were discovered by clinical examination and in an advanced stage. Two of them died early after the diagnosis of PMs (after 4 months and 1 year, respectively). In conclusion, immunosuppression is one of the major risk factors for the development of cSCC and its metastases. It contributes to the poor survival of patients with PMs of the cSCC. Our experience emphasizes the need for the employment of the radiological tests in patients with primary high-risk cSCC to evaluate nonpalpable lymph node involvement.

Keywords: immunosuppression; kidney transplantation; parotid metastases; squamous cell carcinoma; transplant recipients.

PubMed Disclaimer

References

REFERENCES

    1. Madeleine MM, Patel NS, Plasmeijer EI, et al. Epidemiology of keratinocyte carcinomas after organ transplantation. Br J Dermatol. 2017;177(5):1208-1216.
    1. Martinez JC, Otley CC, Stasko T, et al. Defining the clinical course of metastatic skin in organ transplant recipients: a multicenter collaborative study. Arch Dermatol. 2003;139(3):301-306.
    1. Givi B, Andersen PE, Diggs BS, Wax MK, Gross ND. Outcome of patients treated surgically for lymph node metastases from cutaneous squamous cell carcinoma of the head and neck. Head Neck. 2011;33(7):999-1004.
    1. Alam M, Ratner D. Cutaneous squamous-cell carcinoma. N Engl J Med. 2001;344:975-983.
    1. Kwa RE, Campana K, Moy RL. Biology of cutaneous squamous cell carcinoma. J Am Acad Dermatol. 1992;26:1-26.

LinkOut - more resources