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. 2021 Jun;43(6):1797-1811.
doi: 10.1002/hed.26639. Epub 2021 Feb 23.

The prognostic significance of race in nasopharyngeal carcinoma by histological subtype

Katelyn O Stepan  1 , Angela L Mazul  1   2 , S Andrew Skillington  1 , Randal C Paniello  1 , Jason T Rich  1 , Jose P Zevallos  1 , Ryan S Jackson  1 , Patrik Pipkorn  1 , Sean Massa  1 , Sidharth V Puram  1   3
Affiliations

The prognostic significance of race in nasopharyngeal carcinoma by histological subtype

Katelyn O Stepan et al. Head Neck. 2021 Jun.

Abstract

Background: Race has been shown to have variable prognostic importance in nasopharyngeal carcinoma (NPC). However, previous studies are limited by a lack of comprehensive treatment, epidemiologic, and comorbidity data.

Methods: This was a retrospective cohort study utilizing the National Cancer Database from 2004 to 2016. Multivariable Cox proportional hazards regressions were used to calculate adjusted hazard ratios (aHR) for overall survival.

Results: A cohort of 9995 patients met inclusion and exclusion criteria. Race, insurance, comorbidity, treatment, stage, age, and histology were independent prognosticators. Among patients with keratinizing NPC, Asians and Hispanics had superior survival (aHR 0.58 [95% confidence interval (CI) 0.48-0.69], aHR 0.76 [95% CI 0.61-0.96]) compared to white patients. Among patients with non-keratinizing differentiated NPC, Asians and black patients had improved survival (aHR 0.71 [95% CI 0.56-0.91], aHR 0.72 [95% CI 0.54-0.95]) compared to white patients. Race was not prognostic in non-keratinizing undifferentiated NPC.

Conclusion: The prognostic significance of race varies across histological subtypes of NPC.

Keywords: nasopharyngeal carcinoma; prognosis; race; survival.

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Conflict of interest statement

There are no conflicts of interest to disclose.

Figures

Figure 1.
Figure 1.
Percentage cases per year for all cases by A) histological subtype, and by race for B) keratinizing NPC, C) non-keratinizing differentiated NPC, and D) non-keratinizing undifferentiated NPC.
Figure 2.
Figure 2.
Treatment information stratified by TMN stage and race for A) keratinizing NPC, B) non-keratinizing differentiated NPC, and C) non-keratinizing undifferentiated NPC.
Figure 3.
Figure 3.
Kaplan Meier curves for all cases by A) histological subtype, and by race for B) keratinizing NPC, C) non-keratinizing differentiated NPC, and D) non-keratinizing undifferentiated NPC.
See this image and copyright information in PMC

References

    1. Chen YP, Chan ATC, Le QT, Blanchard P, Sun Y, Ma J. Nasopharyngeal carcinoma. Lancet. 2019. doi:10.1016/S0140-6736(19)30956-0 - DOI - PubMed
    1. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018. doi:10.3322/caac.21492 - DOI - PubMed
    1. Mai ZM, Lin JH, Ming Ip DK, et al.Epidemiology and population screening. In: Nasopharyngeal Carcinoma: From Etiology to Clinical Practice.; 2019. doi:10.1016/B978-0-12-814936-2.00004-3 - DOI
    1. Lee AWM, Foo W, Mang O, et al.Changing epidemiology of nasopharyngeal carcinoma in Hong Kong over a 20-year period (1980–99): An encouraging reduction in both incidence and mortality. Int J Cancer. 2003. doi:10.1002/ijc.10894 - DOI - PubMed
    1. Sun LM, Epplein M, Li CI, Vaughan TL, Weiss NS. Trends in the incidence rates of nasopharyngeal carcinoma among Chinese Americans living in Los Angeles County and the San Francisco metropolitan area, 1992–2002. Am J Epidemiol. 2005. doi:10.1093/aje/kwi345 - DOI - PubMed

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