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. 2021 May;32(5):1307-1312.
doi: 10.1007/s00192-021-04711-3. Epub 2021 Feb 23.

Does irritable bowel syndrome increase the risk of interstitial cystitis/bladder pain syndrome? A cohort study of long term follow-up

Kun-Min Chang  1   2 , Ming-Huei Lee  3   4   5 , Hsuan-Hung Lin  2 , Shang-Liang Wu  6 , Huei-Ching Wu  7
Affiliations

Does irritable bowel syndrome increase the risk of interstitial cystitis/bladder pain syndrome? A cohort study of long term follow-up

Kun-Min Chang et al. Int Urogynecol J. 2021 May.

Abstract

Introduction and hypothesis: Interstitial cystitis/bladder pain syndrome (IC/BPS) and irritable bowel syndrome (IBS) often occur concomitantly without an obvious reason. It is important to determine the relationship between these related diseases. We aimed to determine whether IBS increase the risk of IC/BPS.

Methods: We identified newly diagnosed IBS patients between 2002 and 2013 from a nationwide database as the IBS cohort. Subjects diagnosed with IC/BPS before IBS were excluded. Cox's regression analysis with a hazard ratio (HR) of IC/BPS between IBS and the non-IBS cohort was applied to unmatched and matched (16 confounders of propensity scores) models. The time from diagnosis of IBS to IC/BPS was also calculated.

Results: In the unmatched group, which included 100,124 IBS (55% female) and 874,048 non-IBS patients, the IC/BPS adjusted HR was 1.292 (95% confidence interval [CI], 1.131-1.476;p < 0.0001) in the IBS cohort compared with the non-IBS cohort. In the matched group, there were 85,359 patients in each cohort, and the IC/BPS HR was 1.599 (95% CI, 1.344-1.903; p < 0.0001). The average numbers of years until the development of IC/BPS in the IBS cohort and non-IBS cohort were 4.60 ± 2.58 (n = 253) and 5.99 ± 3.49 (n = 295) years, respectively.

Conclusions: IBS was shown to increase the risk of IC/BPS in this 12-year cohort study. The time from the diagnosis of IBS to IC/BPS was 5.35 ± 3.18 years. A common pathophysiology of IBS and IC/BPS is possible. Clinicians should be mindful of the association and promote collaborative care of these two elusive diseases.

Keywords: Bladder pain syndrome; Interstitial cystitis; Irritable bowel syndrome; Pelvic pain; Population-based study.

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References

    1. Hanno P, Dmochowski R. Status of international consensus on interstitial cystitis/bladder pain syndrome/painful bladder syndrome: 2008 snapshot. Neurourol Urodyn. 2009;28(4):274–86. https://doi.org/10.1002/nau.20687 . - DOI - PubMed
    1. Hanno PM. Bladder pain syndrome (interstitial cystitis) and related disorders. In: Wein AJ, Kavoussi LR, Partin AW, Peters CA, editors. Campbell-Walsh urology. 11th ed., chap 14. Philadelphia: Elsevier; 2016.
    1. Leppilahti M, Tammela TLJ, Huhtala H, Auvinen A. Prevalence of symptoms related to interstitial cystitis in women: a population based study in Finland. J Urol. 2002;168(1):139–43. https://doi.org/10.1016/S0022-5347(05)64847-1 . - DOI - PubMed
    1. Clemens JQ, Meenan RT, Rosetti MC, Gao SY, Calhoun EA. Prevalence and incidence of interstitial cystitis in a managed care population. J Urol. 2005;173(1):98–102; discussion 102. https://doi.org/10.1097/01.ju.0000146114.53828.82 . - DOI - PubMed
    1. Sperber AD, Dumitrascu D, Fukudo S, Gerson C, Ghoshal UC, Gwee KA, et al. The global prevalence of IBS in adults remains elusive due to the heterogeneity of studies: a Rome Foundation working team literature review. Gut. 2017;66(6):1075–82. https://doi.org/10.1136/gutjnl-2015-311240 . - DOI - PubMed

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