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Review
. 2021 Apr 1;127(7):1010-1020.
doi: 10.1002/cncr.33433. Epub 2021 Feb 23.

Malignant mesothelioma: Advances in immune checkpoint inhibitor and mesothelin-targeted therapies

Zishuo I Hu  1 , Azam Ghafoor  1 , Manjistha Sengupta  1 , Raffit Hassan  1
Affiliations
Review

Malignant mesothelioma: Advances in immune checkpoint inhibitor and mesothelin-targeted therapies

Zishuo I Hu et al. Cancer. .

Abstract

Malignant mesothelioma is an aggressive cancer with a poor prognosis and limited treatment options. For many years, the only US Food and Drug Administration-approved first-line treatment for unresectable mesothelioma was pemetrexed plus cisplatin. However, the recent approval of nivolumab plus ipilimumab as frontline treatment for patients with pleural mesothelioma marks a significant milestone for the treatment of this disease. In this review, the authors describe recent advances in therapeutic strategies for the treatment of patients with advanced, unresectable mesothelioma, highlighting the emerging use of immunotherapy and mesothelin-targeted therapies for the management of malignant mesothelioma.

Keywords: chimeric antigen receptor T cells (CAR T cells); cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) inhibitor; immunotherapy; mesothelin; mesothelioma; programmed cell death-1/programmed cell death ligand-1 (PD-1/PD-L1) inhibitor.

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Conflict of interest statement

Conflict of interest:

RH has funding for conduct of clinical trials via a cooperative research and development agreement between NCI and Bayer AG and TCR2 Therapeutics. Other authors do not have any conflict of interests.

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