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Comment
. 2021 Feb 22;56(4):400-402.
doi: 10.1016/j.devcel.2021.02.002.

Autophagosome maturation stymied by SARS-CoV-2

Willa Wen-You Yim  1 , Noboru Mizushima  2
Affiliations
Comment

Autophagosome maturation stymied by SARS-CoV-2

Willa Wen-You Yim et al. Dev Cell. .

Abstract

Many pathogens are capable of disrupting autophagy within host cells. In this issue of Developmental Cell, Miao et al. discover that the SARS-CoV-2 protein ORF3a inhibits autophagosome-lysosome fusion by dysregulating the HOPS complex.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Figures

Figure 1
Figure 1
ORF3a of SARS-CoV-2 blocks fusion between autophagosomes/amphisomes and endolysosomes SARS-CoV-2’s ORF3a localizes to late endosomes and lysosomes, where it binds to VPS39 of the HOPS complex. The resulting HOPS complex is unable to mediate STX17-SNAP29-VAMP8 SNARE complex formation. As this SNARE complex mediates autophagosome-lysosome fusion, autophagosomes or amphisomes (autophagosomes that have fused with late endosomes) are unable to mature to autolysosomes in cells with ORF3a.
See this image and copyright information in PMC

Comment on

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