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Comment
. 2021 Jun;37(6):494-495.
doi: 10.1016/j.tig.2021.02.004. Epub 2021 Feb 20.

Uncovering the Mechanical Code of DNA Using 'Loop-seq'

Marek Marzec  1
Affiliations
Comment

Uncovering the Mechanical Code of DNA Using 'Loop-seq'

Marek Marzec. Trends Genet. 2021 Jun.

Abstract

DNA mechanical properties play a critical role in different biological processes. Basu and coworkers described a method that measures DNA mechanics on the genome scale. Access to a high-throughput tool for measuring DNA mechanics opens up new possibilities to investigate this phenomenon with respect to establishing the chromatin regulatory landscape.

Keywords: DNA looping; DNA mechanics; tightly bent DNA.

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  • Measuring DNA mechanics on the genome scale.
    Basu A, Bobrovnikov DG, Qureshi Z, Kayikcioglu T, Ngo TTM, Ranjan A, Eustermann S, Cieza B, Morgan MT, Hejna M, Rube HT, Hopfner KP, Wolberger C, Song JS, Ha T. Basu A, et al. Nature. 2021 Jan;589(7842):462-467. doi: 10.1038/s41586-020-03052-3. Epub 2020 Dec 16. Nature. 2021. PMID: 33328628 Free PMC article.

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