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. 1988;48(4):310-4.
doi: 10.1159/000184949.

A major inhibitor of phenytoin binding to serum protein in uremia

H Mabuchi  1 , H Nakahashi
Affiliations

A major inhibitor of phenytoin binding to serum protein in uremia

H Mabuchi et al. Nephron. 1988.

Abstract

A major endogenous ligand substance, 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF), accumulated in the sera of uremic patients, inhibited phenytoin binding to pooled serum obtained from healthy subjects and to human serum albumin in a concentration usually observed in the sera of patients with uremia. This suggests that CMPF is a major drug-binding inhibitor present in uremic serum and may be one of the so-called 'uremic toxins'.

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