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. 2021 Mar-Apr;35(2):799-803.
doi: 10.21873/invivo.12320.

Significant Association of Chitinase 3-like 1 Genotypes to Asthma Risk in Taiwan

Guan-Liang Chen #  1   2   3 , Shou-Cheng Wang #  2   3 , Te-Chun Shen  1   4   5 , Wen-Shin Chang  1   4 , Chingju Lin  6 , Te-Chun Hsia  4   5 , DA-Tian Bau  7   4   8 , Chia-Wen Tsai  7   4
Affiliations

Significant Association of Chitinase 3-like 1 Genotypes to Asthma Risk in Taiwan

Guan-Liang Chen et al. In Vivo. 2021 Mar-Apr.

Abstract

Background/aim: Chitinase 3-like 1 (CHI3L1) is overexpressed in asthma, and negatively associated with forced expiratory volume in the first second. This study aimed at evaluating whether CHI3L1 genotypes affect asthma risk.

Materials and methods: The blood samples of 198 asthma patients and 453 control subjects were collected, and the genotypic patterns of CHI3L1 -131C/G (rs4950928) and -247G/A (rs1262491437) were examined.

Results: The percentages of CG and GG at CHI3L1 -131C/G were 32.8% and 7.6% among the asthma cases, respectively, significantly higher than the 23.8% and 3.1% among the non-asthmatic healthy subjects (p for trend=0.0009). The allelic frequency distribution analysis showed that the G allele at CHI3L1 - 131C/G conferred a significantly higher asthma risk than the wild-type C allele (p<0.0001). The genotypic and allelic frequency analyses for CHI3L1 -247G/A did not show any significant difference.

Conclusion: The G allele at CHI3L1-131C/G serves as a biomarker in determining personal susceptibility to asthma in Taiwan.

Keywords: Asthma; CHI3L1; Taiwan; genotype; polymorphism.

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Conflict of interest statement

All the Authors have declared no conflicts of interest in relation to this study.

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References

    1. Madore AM, Perron S, Turmel V, Laviolette M, Bissonnette EY, Laprise C. Alveolar macrophages in allergic asthma: an expression signature characterized by heat shock protein pathways. Hum Immunol. 2010;71(2):144–150. doi: 10.1016/j.humimm.2009.11.005. - DOI - PMC - PubMed
    1. Mattiuzzi C, Lippi G. Worldwide asthma epidemiology: insights from the Global Health Data Exchange database. Int Forum Allergy Rhinol. 2020;10(1):75–80. doi: 10.1002/alr.22464. - DOI - PubMed
    1. Masoli M, Fabian D, Holt S, Beasley R, Global Initiative for Asthma P The global burden of asthma: executive summary of the GINA Dissemination Committee report. Allergy. 2004;59(5):469–478. doi: 10.1111/j.1398-9995.2004.00526.x. - DOI - PubMed
    1. Maddox L, Schwartz DA. The pathophysiology of asthma. Annu Rev Med. 2002;53:477–498. doi: 10.1146/annurev.med.53.082901.103921. - DOI - PubMed
    1. Wills-Karp M, Ewart SL. Time to draw breath: asthma-susceptibility genes are identified. Nat Rev Genet. 2004;5(5):376–387. doi: 10.1038/nrg1326. - DOI - PubMed

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