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Case Reports
. 2021 Feb 24:22:e927951.
doi: 10.12659/AJCR.927951.

Complicated Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Syndrome History in a 14-Year-Old

Michael Tomani  1 , Cristina Caridi  1 , Oksana Tatarina-Nulman  1 , Cascya Charlot  1 , Pramod Narula  1
Affiliations
Case Reports

Complicated Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Syndrome History in a 14-Year-Old

Michael Tomani et al. Am J Case Rep. .

Abstract

BACKGROUND Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a drug-induced hypersensitivity reaction that can result in a severe cutaneous adverse drug reaction (SCAR). It is a rare and potentially life-threatening condition that occurs after exposure to sulfonamides, antibiotics, or antiepileptics. Its incidence in children is not established; however, the mortality rate is documented at approximately 10%. DRESS syndrome is believed to result from an interaction between multiple factors, including genetics, abnormalities of metabolism, and reactivation of certain herpes family viruses including EBV and HHV-6. The classic presentation includes fever, rash, and lymphadenopathy. Symptoms begin approximately 3 to 8 weeks after exposure to the offending agent. CASE REPORT We present a unique case of DRESS syndrome in a 14-year-old girl occurring after the ingestion of minocycline and amoxicillin-clavulanic acid (amoxicillin). Identification of the offending agent was complicated by the patient having been on multiple antibiotics within a short timeframe of the initial presentation of symptoms. In addition to swelling and pruritus, the patient experienced vision problems due to papilledema with bilateral hemorrhage. The treatment course was further complicated by a decrease in kidney function, requiring the patient's medication regimen to be adjusted accordingly. CONCLUSIONS This is a unique case of DRESS syndrome demonstrating the potential influence of certain viruses on the severity of its presentation. This case also highlights the need to adjust the steroid regimen to reduce the potentially harmful effects on various organ systems.

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Conflict of interest statement

Conflict of interest: None declared

Conflicts of Interest

None.

Figures

Figure 1.
Figure 1.
Erythematous papules visible on the patient’s arms.
Figure 2.
Figure 2.
The fluctuation of liver enzymes during the patient’s hospitalization period.
Figure 3.
Figure 3.
The fluctuation of BUN levels during the patient’s hospitalization period.
Figure 4.
Figure 4.
The fluctuation of creatinine levels during the patient’s hospitalization period.
See this image and copyright information in PMC

References

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