Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Feb 23;11(1):4350.
doi: 10.1038/s41598-020-79178-1.

Maternal pre-pregnancy body mass index and foetal acidosis in vaginal and caesarean deliveries: The Japan Environment and Children's Study

Tsuyoshi Murata  1   2 , Hyo Kyozuka  3   4 , Akiko Yamaguchi  3   4 , Toma Fukuda  3   4 , Shun Yasuda  3   4 , Akiko Sato  3 , Yuka Ogata  3 , Kosei Shinoki  3 , Mitsuaki Hosoya  3   5 , Seiji Yasumura  3   6 , Koichi Hashimoto  3   5 , Hidekazu Nishigori  3   7 , Keiya Fujimori  3   4 ; Japan Environment and Children’s Study (JECS) Group
Collaborators, Affiliations

Maternal pre-pregnancy body mass index and foetal acidosis in vaginal and caesarean deliveries: The Japan Environment and Children's Study

Tsuyoshi Murata et al. Sci Rep. .

Abstract

A high maternal body mass index (BMI) is associated with increased risks of asphyxia-related neonatal morbidity. We evaluated the association between maternal pre-pregnancy BMI and foetal acidosis while accounting for the mode of delivery. Participants from the Japan Environment and Children's Study with singleton pregnancies after 22 weeks of gestation who gave birth during 2011-2014 were included. The participants (n = 71,799) were categorised into five groups according to the pre-pregnancy BMI: G1 (BMI < 18.5 kg/m2), G2 (18.5 to < 20.0 kg/m2), G3 (20.0 to < 23.0 kg/m2), G4 (23.0 to < 25.0 kg/m2), and G5 (≥ 25.0 kg/m2). Foetal acidosis was defined as umbilical artery pH (UmA-pH) < 7.20 or < 7.10. Multiple logistic regression analyses were used to evaluate the effect of pre-pregnancy BMI on foetal acidosis risk, accounting for the mode of delivery. In Japanese women, pre-pregnancy BMI ≥ 25.0 kg/m2 significantly increased the likelihood of foetal acidosis in newborns delivered vaginally. We found no association between pre-pregnancy BMI and foetal acidosis in newborns delivered via caesarean section. Counselling for body weight control before pregnancy and adequate management and selection of the mode of delivery in pregnant women with a high BMI who are in labour may be essential to avoid foetal acidosis.

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests

Figures

Figure 1
Figure 1
Flowchart of study enrolment.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Owe KM. Weight in early pregnancy and outcomes in early infancy. BMJ. 2014;349:g6850. doi: 10.1136/bmj.g6850. - DOI - PubMed
    1. Jensen MD, et al. 2013 AHA/ACC/TOS guideline for the management of overweight and obesity in adults: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and The Obesity Society. J. Am. Coll. Cardiol. 2014;63:2985–3023. doi: 10.1016/j.jacc.2013.11.004. - DOI - PubMed
    1. Flegal KM, Kruszon-Moran D, Carroll MD, Fryar CD, Ogden CL. Trends in obesity among adults in the United States, 2005 to 2014. JAMA. 2016;315:2284–2291. doi: 10.1001/jama.2016.6458. - DOI - PMC - PubMed
    1. Dudenhausen JW, Grünebaum A, Kirschner W. Prepregnancy body weight and gestational weight gain-recommendations and reality in the USA and in Germany. Am. J. Obstet. Gynecol. 2015;213:591–592. doi: 10.1016/j.ajog.2015.06.016. - DOI - PubMed
    1. Enomoto K, et al. Pregnancy outcomes based on pre-pregnancy body mass index in Japanese women. PLoS ONE. 2016;11:e0157081. doi: 10.1371/journal.pone.0157081. - DOI - PMC - PubMed

Publication types