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. 2020 Sep-Oct;13(5):529-535.
doi: 10.5005/jp-journals-10005-1826.

To Compare the Efficacy of Two Intravenous Combinations of Drugs Ketamine-Propofol vs Ketamine-Dexmedetomidine for Sedation in Children Undergoing Dental Treatment

Aum B Joshi  1 , Ubaradka Raveendra Shankaranarayan  2 , Amitha Hegde  3 , R Manju  3
Affiliations

To Compare the Efficacy of Two Intravenous Combinations of Drugs Ketamine-Propofol vs Ketamine-Dexmedetomidine for Sedation in Children Undergoing Dental Treatment

Aum B Joshi et al. Int J Clin Pediatr Dent. 2020 Sep-Oct.

Abstract

Objective: To compare the efficacy of two intravenous combinations of drugs ketamine-propofol (KP) vs ketamine-dexmedetomidine (KD) for sedation in children undergoing dental treatment.

Study design: Thirty patients were selected, evaluated according to the predetermined criteria and divided in equal numbers of 15 amongst 2 groups KP and KD.

Materials and methods: Informed consent was taken, nil per oral (NPO) guidelines were followed and the study drug was administered. Dental procedure was performed. Heart rate (HR), blood pressure (BP) and oxygen saturation (SPO2) were monitored continuously throughout the procedure. The modified Ramsay sedation (MRS) score was recorded along with Houpt sedation score. Recovery status was accessed by modified Aldrete's recovery scale.

Statistical analysis: Student t test was used for comparing HR, BP and SPO2. Chi-square test was used to compare MRS, Houpt sedation score and modified Aldrete's recovery scale amongst the two groups KP and KD.

Results: The sedation achieved with both the groups was adequate. Both the drugs produce adequate hemodynamic stability.

Conclusion: Ketamine-dexmedetomidine has a better efficacy over the other group, ketamine-propofol.

How to cite this article: Joshi AB, Shankaranarayan UR, Hegde A, et al. To Compare the Efficacy of Two Intravenous Combinations of Drugs Ketamine-Propofol vs Ketamine-Dexmedetomidine for Sedation in Children Undergoing Dental Treatment. Int J Clin Pediatr Dent 2020;13(5):529-535.

Keywords: Dental treatment; Dexmedetomidine; Intravenous sedation; Ketamine; Propofol.

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Conflict of interest statement

Source of support: Nil Conflict of interest: None

Figures

Fig. 1
Fig. 1
Heart rate
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Fig. 2
Systolic blood pressure
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Disatolic blood pressure
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Fig. 4
Modified Ramsay sedation score after the treatment
Fig. 5
Fig. 5
Houpt score for sleep immediately after the delivery of drug
Fig. 6
Fig. 6
Houpt overall sedation score after the treatment
See this image and copyright information in PMC

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