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Case Reports
. 2020 Sep-Oct;13(5):569-571.
doi: 10.5005/jp-journals-10005-1816.

Floating-Harbor Syndrome: A Rare Case Report

Tejaswi Singana  1 , Nelamakanahalli Kempaiah Suma  1 , Anantha Murthy Sankriti  1
Affiliations
Case Reports

Floating-Harbor Syndrome: A Rare Case Report

Tejaswi Singana et al. Int J Clin Pediatr Dent. 2020 Sep-Oct.

Abstract

Aim and objective: To report a case with Floating-Harbor syndrome (FHS), emphasizing the general features and dental abnormalities and the treatment procedures and its outcome.

Background: FHS is an extremely rare genetic disorder, characterized by a triad: short stature, speech delay, and characteristic facies like triangular shape, bulbous nose, wide columella, deep-set eyes, long eyelashes, thin lips, short philtrum, and broad mouth. Approximately 50 cases have been described in the medical literature till date. Diagnosis is often delayed because the characteristic features of this syndrome are nonfamiliar.

Case description: A male child aged 5 years was referred to the dental OPD with the chief complaint of decayed upper and lower front and back teeth. On examination, the patient was found to have FHS along with the dental caries.

Conclusion: FHS is a rare genetic dysmorphic/mental retardation syndrome affecting both sexes but more among the female sex. There is no known cure for the disease and the treatment is symptomatic and supportive.

Clinical significance: An early diagnosis of FHS is important, as it enables with adequate information. These multiple malformations identification by an early diagnosis is crucial, as it requires a multidisciplinary approach in the initial evaluation, treatment, and follow-up.

How to cite this article: Singana T, Suma NK, Sankriti AM. Floating-Harbor Syndrome: A Rare Case Report. Int J Clin Pediatr Dent 2020;13(5):569-571.

Keywords: Clinodactly; Columella; Floating–Harbor syndrome; Microcephaly.

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Conflict of interest statement

Source of support: Nil Conflict of interest: None

Figures

Figs 1A to C
Figs 1A to C
Preoperative photographs
Figs 2A and B
Figs 2A and B
Postoperative photographs
See this image and copyright information in PMC

References

    1. De Benedetto MS, Mendes FM, Hirata S, et al. Floating–Harbor syndrome: case report and craniofacial phenotype characterization. Int J Paediatr Dent. 2004;14(3):208–213. doi: 10.1111/j.1365-263X.2004.00528.x. DOI: - DOI - PubMed
    1. Bastaki L, El Nabi MM, Azab AS, et al. Floating-Harbor syndrome in a Kuwaiti patient: a case report and literature review. East Mediterr Health J. 2007;13(4):975–979. - PubMed
    1. Hood RL, Lines MA, Nikkel SM, et al. Mutations in SRCAP, encoding SNF2-related CREBBP activator protein, cause Floating-Harbor syndrome. Am J Human Genet. 2012;90(2):308–313. doi: 10.1016/j.ajhg.2011.12.001. DOI: - DOI - PMC - PubMed
    1. Arpin S, Afenjar A, Dubern B, et al. Floating-Harbor syndrome: report on a case in a mother and daughter, further evidence of autosomal dominant inheritance. Clin Dysmorphol. 2012;21(1):11–14. doi: 10.1097/MCD.0b013e32834af5a7. DOI: - DOI - PubMed
    1. Holder-Espinasse M, Irving M, Cormier-Daire V. Clinical utility gene card for: 3M syndrome. Eur J Hum Genet. 2011;19(9):1–3. doi: 10.1038/ejhg.2011.32. DOI: - DOI - PMC - PubMed

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