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Review
. 2021 Feb 1:2021:6631757.
doi: 10.1155/2021/6631757. eCollection 2021.

Human Papilloma Virus: Current Knowledge and Focus on Oral Health

Luca Fiorillo  1   2 , Gabriele Cervino  1 , Giovanni Surace  3   4 , Rosa De Stefano  1 , Luigi Laino  2 , Cesare D'Amico  1 , Maria Teresa Fiorillo  4 , Aida Meto  5 , Alan Scott Herford  6 , Alina Vladimirovna Arzukanyan  7 , Gianrico Spagnuolo  7   8 , Marco Cicciù  1
Affiliations
Review

Human Papilloma Virus: Current Knowledge and Focus on Oral Health

Luca Fiorillo et al. Biomed Res Int. .

Abstract

The human papilloma virus (HPV) is responsible for different pathological manifestations in humans. This agent gives rise to lesions of different types and in different areas of the organism, including the oral cavity. The aim of this study is to show which are the main diseases for which HPV is responsible and to bring to light some of the interceptive and therapeutic strategies. The analysis was conducted by consulting the major scientific databases with the aim of obtaining information on the characteristics of oral HPV and its management; furthermore, the literature was supported by some clinical cases proposed by the authors. The role of dentistry is essential in the early diagnosis of this type of pathologies and above all in knowing how to direct patients towards a path that can lead to patient management, especially in the event that these lesions have a malignant potential. Enhancing the knowledge and role of dentistry can lead to early diagnosis of this type of injury, intercepting a pathology that could have multiorgan implications.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Identification, screening, and eligibility phase of literature, according to PRISMA.
Figure 2
Figure 2
Oral HPV lesion. With gentle permission from Prof. L. Laino.
Figure 3
Figure 3
Oral HPV lesion. With gentle permission from Prof. L. Laino.
Figure 4
Figure 4
Histology of the lesions. Diagnosis of squamous cell papilloma (20 × 20 magnification).
Figure 5
Figure 5
Clinical photograph of the palatal lesion. With gentle permission from Dr. Luca Fiorillo.
See this image and copyright information in PMC

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References

    1. Strickley J. D., Messerschmidt J. L., Awad M. E., et al. Immunity to commensal papillomaviruses protects against skin cancer. Nature. 2019;575(7783):519–522. doi: 10.1038/s41586-019-1719-9. - DOI - PMC - PubMed
    1. Scudellari M. HPV: Sex, cancer and a virus. Nature. 2013;503(7476):330–332. doi: 10.1038/503330a. - DOI - PubMed
    1. Crow J. M. HPV: the global burden. Nature. 2012;488(7413):S2–S3. doi: 10.1038/488S2a. - DOI - PubMed
    1. Zelkowitz R. Cancer. HPV casts a wider shadow. Science. 2009;323(5914):580–581. doi: 10.1126/science.323.5914.580. - DOI - PubMed
    1. Cohen J. Public health. HPV's peculiarities, from infection to disease. Science. 2005;308(5722) doi: 10.1126/science.308.5722.619. - DOI - PubMed

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