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. 2021 Feb 2;16(1):264-273.
doi: 10.1515/med-2021-0214. eCollection 2021.

Intestinal fatty acid-binding protein as a biomarker for the diagnosis of strangulated intestinal obstruction: A meta-analysis

Caihong Wu  1 , Xuehe Zhu  1 , Haipeng Ren  1 , Fuyong Tan  2 , Xudong Liu  1
Affiliations

Intestinal fatty acid-binding protein as a biomarker for the diagnosis of strangulated intestinal obstruction: A meta-analysis

Caihong Wu et al. Open Med (Wars). .

Abstract

Objective: The purpose of this study was to clarify the value of intestinal fatty acid-binding protein (I-FABP) for the early diagnosis of strangulated intestinal obstruction through a meta-analysis.

Methods: A search was performed on PubMed, EBSCO, the Cochrane Library, the Web of Science, EMBASE, CNKI, and WanFang for studies on the diagnosis of strangulated intestinal obstruction based on I-FABP. Endnote X9 software and the quality assessment of diagnostic accuracy studies 2 (QUADAS-2) were used to screen the studies and evaluate their quality, respectively. Meta-Disc 1.4 and Stata 15.1 software were used to perform the assessment of heterogeneity and meta-analysis.

Result: A total of eight studies were included, Spearman correlation coefficient was 0.703 (P = 0.078), suggesting that there was no threshold effect. The pooled results of the meta-analysis were as follows: sensitivity: 0.75 (95% CI: 0.66-0.81), specificity: 0.83 (95% CI: 0.71-0.91), positive likelihood ratio (PLR): 4.35 (95% CI: 2.57-7.36), negative likelihood ratio (NLR): 0.31 (95% CI: 0.24-0.39), and diagnostic odds ratio (DOR): 14.19 (95% CI: 8.08-24.92). The area under the curve was 0.83. There was obvious heterogeneity among the studies.

Conclusion: I-FABP is very valuable for the early diagnosis of strangulated intestinal obstruction and can be used to distinguish strangulated intestinal obstruction from intestinal obstruction in a timely manner, enabling accurate planning of the timing of surgery.

Keywords: diagnostic value; intestinal fatty acid-binding protein; meta-analysis; strangulated intestinal obstruction.

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Conflict of interest statement

Conflict of interest: The authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
The flow chart of study inclusion in the meta-analysis.
Figure 2
Figure 2
The forest plot of the diagnostic sensitivity and specificity for serum I-FABP in diagnosis of strangulated intestinal obstruction.
Figure 3
Figure 3
The forest plot of the diagnostic PLR and NLR for serum I-FABP in diagnosis of strangulated intestinal obstruction.
Figure 4
Figure 4
The forest plot of the DOR for serum I-FABP in diagnosis of strangulated intestinal obstruction.
Figure 5
Figure 5
Serum I-FABP for the diagnosis of strangulated intestinal obstruction. A. ROC curve. B. Meta-regression.
Figure 6
Figure 6
Sensitivity analysis of serum I-FABP for the diagnosis of strangulated intestinal obstruction.
Figure 7
Figure 7
Publication bias evaluated by Deeks funnel plot.
See this image and copyright information in PMC

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