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Case Reports
. 2021 Nov 1;43(8):e1156-e1158.
doi: 10.1097/MPH.0000000000002090.

Successful High-dose Chemotherapy in Combination With Autologous Peripheral Blood Stem Cell Transplantation in an Anuric Child With Neuroblastoma

Tomohiro Inoguchi  1 , Riku Hamada  1 , Wataru Kubota  1 , Chikako Terano  1 , Ryoko Harada  1 , Masataka Honda  1 , Shoko Yamaoka  2 , Yuichi Yokokawa  2 , Yuki Yuza  2 , Hiroshi Hataya  1
Affiliations
Case Reports

Successful High-dose Chemotherapy in Combination With Autologous Peripheral Blood Stem Cell Transplantation in an Anuric Child With Neuroblastoma

Tomohiro Inoguchi et al. J Pediatr Hematol Oncol. .

Abstract

No reports describe high-dose chemotherapy (HDCT) with autologous peripheral blood stem cell transplantation (auto-PBSCT) in pediatric patients with neuroblastoma and end-stage renal disease. Here, we report the case of a patient with high-risk neuroblastoma who developed anuria during treatment. HDCT with auto-PBSCT under hemodialysis, with strict attention to the ultrafiltration volume and dose modification of alkylating agents, was performed. Although the first auto-PBSCT led to engraftment failure, the second auto-PBSCT resulted in successful myeloid engraftment 8 months after anuria. This case demonstrated that HDCT with auto-PBSCT can be safely performed in children with renal failure under hemodialysis.

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Conflict of interest statement

The authors declare no conflict of interest.

References

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