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Comment
. 2021 Apr 5;218(4):e20202507.
doi: 10.1084/jem.20202507.

TRPA1: An asthma target with a zing

Sven-Eric Jordt  1   2   3
Affiliations
Comment

TRPA1: An asthma target with a zing

Sven-Eric Jordt. J Exp Med. .

Abstract

Asthma therapy has advanced remarkably; however, a significant number of patients respond poorly to current interventions. Balestrini et al. (2021. J. Exp. Med.https://doi.org/10.1084/jem.20201637) advance the concept that sensory nerves control inflammation in asthma, demonstrating that a novel inhibitor of TRPA1, a nerve receptor for irritants and reactive endogenous mediators, suppresses inflammation and airway smooth muscle contraction in several preclinical species.

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Conflict of interest statement

Disclosures: S.-E. Jordt served on the scientific advisory board of Hydra Biosciences, a company developing TRP channel inhibitors for the treatment of pain and inflammation.

Figures

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Insights from Sven-Eric Jordt.
See this image and copyright information in PMC

Comment on

  • A TRPA1 inhibitor suppresses neurogenic inflammation and airway contraction for asthma treatment.
    Balestrini A, Joseph V, Dourado M, Reese RM, Shields SD, Rougé L, Bravo DD, Chernov-Rogan T, Austin CD, Chen H, Wang L, Villemure E, Shore DGM, Verma VA, Hu B, Chen Y, Leong L, Bjornson C, Hötzel K, Gogineni A, Lee WP, Suto E, Wu X, Liu J, Zhang J, Gandham V, Wang J, Payandeh J, Ciferri C, Estevez A, Arthur CP, Kortmann J, Wong RL, Heredia JE, Doerr J, Jung M, Vander Heiden JA, Roose-Girma M, Tam L, Barck KH, Carano RAD, Ding HT, Brillantes B, Tam C, Yang X, Gao SS, Ly JQ, Liu L, Chen L, Liederer BM, Lin JH, Magnuson S, Chen J, Hackos DH, Elstrott J, Rohou A, Safina BS, Volgraf M, Bauer RN, Riol-Blanco L. Balestrini A, et al. J Exp Med. 2021 Apr 5;218(4):e20201637. doi: 10.1084/jem.20201637. J Exp Med. 2021. PMID: 33620419 Free PMC article. Clinical Trial.

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