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. 2021 Apr;78(4):1227-1237.
doi: 10.1007/s00284-021-02389-w. Epub 2021 Feb 24.

Antibiotic Resistance in Pseudomonas spp. Through the Urban Water Cycle

Anca Butiuc-Keul  1   2 , Rahela Carpa  1   2 , Dorina Podar  1   2 , Edina Szekeres  3 , Vasile Muntean  1   2 , Dumitrana Iordache  1   2 , Anca Farkas  4   5
Affiliations

Antibiotic Resistance in Pseudomonas spp. Through the Urban Water Cycle

Anca Butiuc-Keul et al. Curr Microbiol. 2021 Apr.

Abstract

Selection and dissemination of resistant bacteria and antibiotic resistance genes (ARGs) require a deeper understanding since antibiotics are permanently released to the environment. The objective of this paper was to evaluate the phenotypic resistance of 499 isolates of Pseudomonas spp. from urban water sources, and the prevalence of 20 ARGs within those isolates. Resistance to penicillins, cephalosporins, carbapenems, quinolones, macrolides, and tetracyclines was mainly observed in the hospital effluent, municipal wastewater and river water downstream the city. Resistant strains were frequently identified as P. aeruginosa and P. putida. P. aeruginosa isolates were mostly resistant to cefepime, ceftazidime, imipenem, and gentamycin, while P. putida strains were especially resistant to piperacillin-tazobactam. ARGs such as blaTEM-1, blaSHV-1, blaPER-1, blaAmpC, blaVIM-1, PstS, qnrA, qnrB, ermB, tetA, tetB and tetC have been detected. The blaAmpC gene was found in P. aeruginosa, while blaTEM-1 and blaPER-1 genes were found in P. putida. Class 1 integron integrase gene was found in 6.81% of the Pseudomonas isolates.

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References

    1. Meyer E, Gastmeier P, Deja M, Schwab F (2013) Antibiotic consumption and resistance: data from Europe and Germany. Int J Med Microbiol 303:388–395 - PubMed - DOI
    1. Chao Y, Ma L, Yang Y, Ju F, Zhang X-X, Wu W-M, Zhang T (2013) Metagenomic analysis reveals significant changes of microbial compositions and protective functions during drinking water treatment. Sci Rep. https://doi.org/10.1038/srep03550 - PubMed - PMC - DOI
    1. Gruber I, Heudorf U, Werner G, Pfeifer Y, Imirzalioglu C, Ackermann H, Brandt C, Besier S, Wichelhaus TA (2013) Multidrug-resistant bacteria in geriatric clinics, nursing homes, and ambulant care-prevalence and risk factors. Int J Med Microbiol 303:405–409 - PubMed - DOI
    1. Martins VV, Zanetti MOB, Pitondo-Silva A, Stehling EG (2014) Aquatic environments polluted with antibiotics and heavy metals: a human health hazard. Environ Sci Pollut Res 21:5873–5878 - DOI
    1. Nõlvak H, Truu M, Kanger K, Tampere M, Espenberg M, Loit E, Raave H, Truu J (2016) Inorganic and organic fertilizers impact the abundance and proportion of antibiotic resistance and integron-integrase genes in agricultural grassland soil. Sci Total Environ 562:678–689 - PubMed - DOI

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