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Meta-Analysis
. 2022 Feb;67(2):716-728.
doi: 10.1007/s10620-021-06885-8. Epub 2021 Feb 24.

Endoscopic Bilateral Stent-in-Stent Versus Stent-by-Stent Deployment in Advanced Malignant Hilar Obstruction: A Meta-Analysis and Systematic Review

Sung Ryul Shim  1   2 , Tae Hoon Lee  3   4 , Jae Kook Yang  5 , Jae Heon Kim  2 , Yun Nah Lee  6 , Sang-Woo Cha  7 , Jong Ho Moon  6 , Young Deok Cho  7 , Sang-Heum Park  5
Affiliations
Meta-Analysis

Endoscopic Bilateral Stent-in-Stent Versus Stent-by-Stent Deployment in Advanced Malignant Hilar Obstruction: A Meta-Analysis and Systematic Review

Sung Ryul Shim et al. Dig Dis Sci. 2022 Feb.

Abstract

Background and aim: There is no clear data to compare the effectiveness and safety of bilateral stent-in-stent (SIS) or stent-by-stent (SBS) deployment for advanced malignant hilar obstruction (MHO). This meta-analysis was done to investigate clinical outcomes of these deployment methods.

Methods: We did a literature search to identify studies that reported the clinical outcomes of bilateral metal stents in patients with advanced MHO. Weighed pooled rates (WPR) along with 95% confidence interval (95% CI) were calculated in order to compare outcomes including technical and clinical success, adverse events, and stent occlusion between the two groups. We conducted a meta-analysis using a random-effects model.

Results: Five comparative studies with 250 patients, and 20 single-arm studies for the SIS or SBS method were eligible for the meta-analysis and systematic review. The bilateral SIS deployment had a significantly higher technical success rate than did SBS deployment (OR 6.43; 95% CI 1.08-38.09). There was no difference in the clinical success (OR 1.23; 95% CI 0.45-3.38), overall adverse events rates (OR 0.42; 95% CI 0.15-1.18), or overall occlusion rate (OR 1.55; 95% CI 0.89-2.70). As a single-armed group, WPR of technical success of the SIS and SBS groups was 96.4% and 89.6%, respectively. Clinical success was 97.5% and 98.3%. Overall, adverse events were 35.9% and 22.6%. Occlusion rates were 27.7% and 37.7%.

Conclusions: Although there was a lack of quality data and heterogeneity, bilateral SIS deployment had a higher technical feasibility than did the SBS method in patients with advanced MHO, without differences in terms of clinical success, adverse events, or occlusion rates.

Keywords: Bilateral; Hilar; Metal; Stent-by-stent; Stent-in-stent.

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References

    1. Naitoh I, Hayashi K, Nakazawa T et al. Side-by-side versus stent-in-stent deployment in bilateral endoscopic metal stenting for malignant hilar biliary obstruction. Dig Dis Sci. 2012;57:3279–3285. - DOI
    1. Kim KM, Lee KH, Chung YH et al. A comparison of bilateral stenting methods for malignant hilar biliary obstruction. Hepatogastroenterology. 2012;59:341–346. - DOI
    1. Law R, Baron TH. Bilateral metal stents for hilar biliary obstruction using a 6Fr delivery system: outcomes following bilateral and side-by-side stent deployment. Dig Dis Sci. 2013;58:2667–2672. - DOI
    1. Lee TH, Moon JH, Choi JH et al. Prospective comparison of endoscopic bilateral stent-in-stent versus stent-by-stent deployment for inoperable advanced malignant hilar biliary stricture. Gastrointest Endosc. 2019;90:222–230. - DOI
    1. Ishigaki K, Hamada T, Nakai Y et al. Retrospective comparative study of side-by-side and stent-in-stent metal stent placement for hilar malignant biliary obstruction. Dig Dis Sci. 2020;65:3710–3718. - DOI

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