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. 2021 Jul;65(1):22-29.
doi: 10.1165/rcmb.2020-0397WS.

National Heart, Lung, and Blood Institute and Building Respiratory Epithelium and Tissue for Health (BREATH) Consortium Workshop Report: Moving Forward in Lung Regeneration

Robert E Hynds  1   2 , William J Zacharias  3 , Marko Z Nikolić  2 , Melanie Königshoff  4   5 , Oliver Eickelberg  4 , Reinoud Gosens  6   7 , Paolo de Coppi  8 , Sam M Janes  2 , Edward Morrisey  9   10   11 , Hans Clevers  12   13   14 , Amy L Ryan  15   16 , Barry R Stripp  17   18 , Xin Sun  19   20 , Carla F Kim  21   22   23   24 , Qing S Lin  25
Affiliations

National Heart, Lung, and Blood Institute and Building Respiratory Epithelium and Tissue for Health (BREATH) Consortium Workshop Report: Moving Forward in Lung Regeneration

Robert E Hynds et al. Am J Respir Cell Mol Biol. 2021 Jul.

Abstract

The National Heart, Lung, and Blood Institute of the National Institutes of Health, together with the Longfonds BREATH consortium, convened a working group to review the field of lung regeneration and suggest avenues for future research. The meeting took place on May 22, 2019, at the American Thoracic Society 2019 conference in Dallas, Texas, United States, and brought together investigators studying lung development, adult stem-cell biology, induced pluripotent stem cells, biomaterials, and respiratory disease. The purpose of the working group was 1) to examine the present status of basic science approaches to tackling lung disease and promoting lung regeneration in patients and 2) to determine priorities for future research in the field.

Keywords: chronic lung disease; lung injury; lung regeneration; stem cells.

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Figures

Figure 1.
Figure 1.
An integrated approach to the development of lung regenerative therapies. EVLP = ex vivo lung perfusion; HTS = high-throughput screening; iPSC = induced pluripotent stem cell.
See this image and copyright information in PMC

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