Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2020 Dec;31(12):853-859.
doi: 10.5152/tjg.2020.19699.

Eradication of Helicobacter Pylori Infections and GERD: A systematic review and meta-analysis

Wen-Ling Mou  1 , Meng-Yao Feng  2 , Li-Hua Hu  1
Affiliations
Meta-Analysis

Eradication of Helicobacter Pylori Infections and GERD: A systematic review and meta-analysis

Wen-Ling Mou et al. Turk J Gastroenterol. 2020 Dec.

Abstract

Background/aims: This study evaluates the association between the eradication of Helicobacter pylori (H. pylori) and gastroesophageal reflux disease (GERD).

Materials and methods: Relevant studies were identified by conducting literature search in PubMed, Cochrane, Embase, CNKI, VANFUN, and VIP databases. The prevalence rates of gastroesophageal reflux, heartburn, epigastric pain, and nausea were extracted from the identified research articles and were used in meta-analysis of relative risks (RR) to achieve an overall effect size of the relationship between H. pylori eradication and GERD.

Results: A total of 19 randomized controlled trials were included in this meta-analysis. The prevalence of gastroesophageal reflux was significantly higher in patients with H. pylori eradication compared with patients without it (RR: 1.54, 95% CI: 1.06-2.24; p=0.02). A subgroup analysis did not identify any significant difference in GERD prevalence in studies conducted outside China (RR: 1.62, 95% CI: 0.98-2.68) or in China (RR: 1.30, 95% CI: 0.76-2.22). There were no significant differences in heartburn (RR: 1.03, 95% CI: 0.88-1.20), epigastric pain (RR: 0.98, 95% CI: 0.13-7.56), or nausea (RR: 0.44, 95% CI: 0.07-2.72) risk between patients with and without H. pylori eradication.

Conclusion: Eradication of H. pylori infection is found to be associated with GERD, although regional differences may exist in the prevalence. Well-designed studies especially those with stratification of patients' basic conditions are needed to seek refined evidence of the association between H. pylori eradication and the GERD.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: The authors have no conflict of interest to declare.

Figures

Figure 1
Figure 1
A flowchart of the study screening and selection strategy.
Figure 2
Figure 2
A forest plot showing the overall relative risk of esophageal reflux prevalence between H. pylori eradication and control groups and the subgroup effect sizes for the studies conducted in China and outside China.
Figure 3
Figure 3
A forest plot showing the pooled analysis of the risk ratio of heartburn, epigastric pain, and nausea prevalence between H. pylori eradication and control groups.
Figure 4
Figure 4
A funnel plot of log RR of esophageal reflux showing the absence of publication bias.
See this image and copyright information in PMC

References

    1. Vakil N, van Zanten SV, Kahrilas P, Dent J, Jones R Global Consensus Group. The Montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensus. Am J Gastrornterol. 2006;101:1900–20. doi: 10.1111/j.1572-0241.2006.00630.x. - DOI - PubMed
    1. NIH Consensus Conference. Helicobacter pylori in peptic ulcer disease. NIH Consensus Development Panel on Helicobacter pylori in peptic ulcer disease. JAMA. 1994;272:65–9. doi: 10.1001/jama.272.1.65. - DOI - PubMed
    1. Stadtlander CT, Waterbor JW. Molecular epidemiology, pathogenesis and prevention of gastric cancer. Carcinogenesis. 1999;20:2195–208. doi: 10.1093/carcin/20.12.2195. - DOI - PubMed
    1. Nomura AM, Kolonel LN, Miki K, et al. Helicobacter pylori, pepsinogen, and gastric adenocarcinoma in Hawaii. J Infect Dis. 2005;191:2075–81. doi: 10.1086/430353. - DOI - PubMed
    1. Choi IJ, Kim CG, Lee JY, et al. Family history of gastric cancer and helicobacter pylori treatment. N Engl J Med. 2020;382:427–36. doi: 10.1056/NEJMoa1909666. - DOI - PubMed

MeSH terms

Substances