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Comment
. 2021 May:95:102371.
doi: 10.1016/j.ceca.2021.102371. Epub 2021 Feb 18.

Blue light opens the ORAI1 LOC(K)

Sonal Srikanth  1 , Yousang Gwack  2
Affiliations
Comment

Blue light opens the ORAI1 LOC(K)

Sonal Srikanth et al. Cell Calcium. 2021 May.

Abstract

The current optogenetic tools to elevate cytoplasmic Ca2+ concentrations either do not have high ion selectivity or activate undesirable signaling pathways. He et al. (2021) generated a light-operated Ca2+ channel by integrating a photosensitive module directly into ORAI1 channels to selectively raise cytoplasmic Ca2+ levels.

Keywords: Light-operated Ca(2+) channel; Orai1; STIM1.

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