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Case Reports
. 2021 Mar-Apr:65:143-145.
doi: 10.1016/j.jelectrocard.2021.01.022. Epub 2021 Feb 13.

KCNE2 gene mutation and Brugada syndrome

Ioannis Liatakis  1 , Malena P Pantou  2 , Polyxeni Gourzi  2 , George Bazoukis  1 , Panagiotis Mililis  1 , Athanasios Saplaouras  1 , Konstantinos Vlachos  1 , Efstathia Prappa  1 , Dimitrios Degiannis  2 , Michael Efremidis  1 , Konstantinos P Letsas  3
Affiliations
Case Reports

KCNE2 gene mutation and Brugada syndrome

Ioannis Liatakis et al. J Electrocardiol. 2021 Mar-Apr.

Abstract

KCNE2 gene mutations have been associated with atrial fibrillation, long QT syndrome, Brugada syndrome and unexplained sudden cardiac death. Herein, we describe a case of Brugada syndrome carrying an heterozygous variant in the KCNE2 gene [NM_172201.2:c.161 T > C, p.(Met54Thr, M54T)]. Gain of function of the Ito current possibly explains the Brugada ECG phenotype in this case.

Keywords: Brugada syndrome; KCNE2 gene; Mutation.

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Declaration of Competing Interest None to declare.

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