This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features!

Skip to main page content

Add to Collections

Your saved search

Name of saved search:

Search terms:

Test search terms

Would you like email updates of new search results?

Yes
No

Email: (change)

Frequency:

Which day?

Which day?

Report format:

Send at most:

Send even when there aren't any new results

Optional text in email:

Your RSS Feed

Review

. 2021 Apr;41(4):1265-1283.

doi: 10.1161/ATVBAHA.120.311911. Epub 2021 Feb 25.

Vascular Hypothesis of Alzheimer Disease: Topical Review of Mouse Models

Sanny Scheffer¹, Dorien M A Hermkens¹, Louise van der Weerd², Helga E de Vries³, Mat J A P Daemen¹

Affiliations

Affiliations

¹ Department of Pathology, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, the Netherlands (S.S., D.M.A.H., M.J.A.P.D.).
² Departments of Radiology & Human Genetics, Leiden University Medical Center, the Netherlands (L.v.d.W.).
³ Department of Molecular Cell Biology and Immunology, Amsterdam Neuroscience, Amsterdam UMC, Vrije University of Amsterdam, the Netherlands (H.E.d.V.).

PMID: 33626911
DOI: 10.1161/ATVBAHA.120.311911

Free article

Review

Vascular Hypothesis of Alzheimer Disease: Topical Review of Mouse Models

Sanny Scheffer et al. Arterioscler Thromb Vasc Biol. 2021 Apr.

Free article

. 2021 Apr;41(4):1265-1283.

doi: 10.1161/ATVBAHA.120.311911. Epub 2021 Feb 25.

Authors

Sanny Scheffer¹, Dorien M A Hermkens¹, Louise van der Weerd², Helga E de Vries³, Mat J A P Daemen¹

Affiliations

¹ Department of Pathology, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, the Netherlands (S.S., D.M.A.H., M.J.A.P.D.).
² Departments of Radiology & Human Genetics, Leiden University Medical Center, the Netherlands (L.v.d.W.).
³ Department of Molecular Cell Biology and Immunology, Amsterdam Neuroscience, Amsterdam UMC, Vrije University of Amsterdam, the Netherlands (H.E.d.V.).

PMID: 33626911
DOI: 10.1161/ATVBAHA.120.311911

Abstract

[Figure: see text].

Keywords: Alzheimer disease; cardiovascular disease; cerebral hemodynamics; dementia; vascular risk factors.

PubMed Disclaimer

Similar articles

Impact of Cardiovascular Hemodynamics on Cognitive Aging.
Moore EE, Jefferson AL. Moore EE, et al. Arterioscler Thromb Vasc Biol. 2021 Apr;41(4):1255-1264. doi: 10.1161/ATVBAHA.120.311909. Epub 2021 Feb 11. Arterioscler Thromb Vasc Biol. 2021. PMID: 33567862 Free PMC article. Review.
Vascular Contributions to Cognitive Impairment and Dementia: Topical Review of Animal Models.
Madigan JB, Wilcock DM, Hainsworth AH. Madigan JB, et al. Stroke. 2016 Jul;47(7):1953-9. doi: 10.1161/STROKEAHA.116.012066. Epub 2016 Jun 14. Stroke. 2016. PMID: 27301939 Free PMC article. Review. No abstract available.
High Systolic Blood Pressure Induces Cerebral Microvascular Endothelial Dysfunction, Neurovascular Unit Damage, and Cognitive Decline in Mice.
de Montgolfier O, Pinçon A, Pouliot P, Gillis MA, Bishop J, Sled JG, Villeneuve L, Ferland G, Lévy BI, Lesage F, Thorin-Trescases N, Thorin É. de Montgolfier O, et al. Hypertension. 2019 Jan;73(1):217-228. doi: 10.1161/HYPERTENSIONAHA.118.12048. Hypertension. 2019. PMID: 30571552
Cerebrovascular resistance: effects on cognitive decline, cortical atrophy, and progression to dementia.
Yew B, Nation DA; Alzheimer’s Disease Neuroimaging Initiative. Yew B, et al. Brain. 2017 Jul 1;140(7):1987-2001. doi: 10.1093/brain/awx112. Brain. 2017. PMID: 28575149 Free PMC article.
Neurovascular dysfunction, inflammation and endothelial activation: implications for the pathogenesis of Alzheimer's disease.
Grammas P. Grammas P. J Neuroinflammation. 2011 Mar 25;8:26. doi: 10.1186/1742-2094-8-26. J Neuroinflammation. 2011. PMID: 21439035 Free PMC article. Review.

See all similar articles

Cited by

Neuro-Nutraceutical Polyphenols: How Far Are We?
Gentile MT, Camerino I, Ciarmiello L, Woodrow P, Muscariello L, De Chiara I, Pacifico S. Gentile MT, et al. Antioxidants (Basel). 2023 Feb 21;12(3):539. doi: 10.3390/antiox12030539. Antioxidants (Basel). 2023. PMID: 36978787 Free PMC article. Review.
Diets to promote healthy brain ageing.
Charisis S, Yannakoulia M, Scarmeas N. Charisis S, et al. Nat Rev Neurol. 2025 Jan;21(1):5-16. doi: 10.1038/s41582-024-01036-9. Epub 2024 Nov 21. Nat Rev Neurol. 2025. PMID: 39572782 Review.
Loss of Direct Vascular Contact to Astrocytes in the Hippocampus as an Initial Event in Alzheimer's Disease. Evidence from Patients, In Vivo and In Vitro Experimental Models.
Pomilio C, Presa J, Oses C, Vinuesa A, Bentivegna M, Gregosa A, Riudavets M, Sevlever G, Galvan V, Levi V, Beauquis J, Saravia F. Pomilio C, et al. Mol Neurobiol. 2024 Aug;61(8):5142-5160. doi: 10.1007/s12035-023-03897-5. Epub 2024 Jan 3. Mol Neurobiol. 2024. PMID: 38172288
Type 2 Diabetes Mellitus and Alzheimer's Disease: Shared Molecular Mechanisms and Potential Common Therapeutic Targets.
Hamzé R, Delangre E, Tolu S, Moreau M, Janel N, Bailbé D, Movassat J. Hamzé R, et al. Int J Mol Sci. 2022 Dec 4;23(23):15287. doi: 10.3390/ijms232315287. Int J Mol Sci. 2022. PMID: 36499613 Free PMC article. Review.
A Systematic Review of the Effects of Capsaicin on Alzheimer's Disease.
Inyang D, Saumtally T, Nnadi CN, Devi S, So PW. Inyang D, et al. Int J Mol Sci. 2023 Jun 15;24(12):10176. doi: 10.3390/ijms241210176. Int J Mol Sci. 2023. PMID: 37373321 Free PMC article.

See all "Cited by" articles

Publication types

Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

LinkOut - more resources

Full Text Sources
- Atypon
- Ovid Technologies, Inc.
Other Literature Sources
- The Lens - Patent Citations Database
- scite Smart Citations
Medical
- MedlinePlus Health Information