Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2021 Mar-Apr;96(2):184-187.
doi: 10.1016/j.abd.2020.06.010. Epub 2021 Feb 4.

Cutaneous smooth muscle tumors associated with Epstein-Barr virus in an adult patient with HIV

Estefania Galeano-Piedrahita  1 , Ana Maria Maya Rico  2 , Ana Cristina Ruiz Suárez  2 , Andrea Laverde Walter  2
Affiliations
Case Reports

Cutaneous smooth muscle tumors associated with Epstein-Barr virus in an adult patient with HIV

Estefania Galeano-Piedrahita et al. An Bras Dermatol. 2021 Mar-Apr.

Abstract

Epstein Barr virus-associated smooth muscle tumors are an uncommon neoplasm that occurs in immunosuppressed patients of any age. Usually, it presents as multifocal tumors mainly in the spinal cord, epidural region, gastrointestinal tract and liver, upper respiratory tract and skin, the latest with few cases reported in the literature and related with human immunodeficiency virus infection and acquired immune deficiency syndrome. The authors present the first case of a Colombian adult patient with human immunodeficiency virus infection and multifocal Epstein Barr virus-associated smooth muscle tumors in the skin and epidural region, confirmed by histopathology, immunohistochemistry and in situ hybridization studies.

Keywords: Epstein-Barr virus infections; HIV; Skin manifestations; Smooth muscle tumor.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Linear subcutaneous nodule on the dorsum of the right hand.
Figure 2
Figure 2
Nuclear magnetic resonance of the spine with epidural infiltration and foraminal involvement of T11 and T12, with compression and displacement of the spinal cord.
Figure 3
Figure 3
Subcutaneous nodule. (A and B), well circumscribed nodular formation formed by spindle cell bundles with minimal atypia and few mitotic figures (Hematoxylin & eosin ×100 and ×400, respectively). (C and D), SMA and H-caldesmon positive immunohistochemistry, respectively.
Figure 4
Figure 4
Epidural lesion. (A and B), confused lesion by spindle cell bundles with low atypia (Hematoxylin & eosin ×100 and ×400, respectively). (C and D), SMA and H-caldesmon positive immunohistochemistry, respectively.
Figure 5
Figure 5
In situ hybridization study for detection of Epstein-Barr virus.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Dekate J., Chetty R. Epstein-Barr virus-associated smooth muscle tumor. Arch Pathol Lab Med. 2016;140:718–722. - PubMed
    1. McClain K.L., Leach C.T., Jenson H.B., Joshi V.V., Pollock B.H., Parmley R.T. Association of Epstein-Barr virus with leiomyosarcomas in young people with AIDS. N Engl J Med. 1995;332:12–18. - PubMed
    1. Issarachaikul R., Shuangshoti S., Suankratay C. Epstein-Barr virus-associated smooth muscle tumors in AIDS patients: a largest case (series) Intern Med. 2014;53:2391–2396. - PubMed
    1. Purgina B., Rao U.N.M., Miettinen M., Pantanowitz L. AIDS-related EBV-associated smooth muscle tumors: a review of 64 published cases. Patholog Res Int. 2011;2011:561548. - PMC - PubMed
    1. Pritzker K.P., Huang S.N., Marshall K.G. Malignant tumours following immunosuppressive therapy. Can Med Assoc J. 1970;103:1362–1365. - PMC - PubMed

Publication types