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Case Reports
. 2021 Mar-Apr;96(2):184-187.
doi: 10.1016/j.abd.2020.06.010. Epub 2021 Feb 4.

Cutaneous smooth muscle tumors associated with Epstein-Barr virus in an adult patient with HIV

Estefania Galeano-Piedrahita  1 , Ana Maria Maya Rico  2 , Ana Cristina Ruiz Suárez  2 , Andrea Laverde Walter  2
Affiliations
Case Reports

Cutaneous smooth muscle tumors associated with Epstein-Barr virus in an adult patient with HIV

Estefania Galeano-Piedrahita et al. An Bras Dermatol. 2021 Mar-Apr.

Abstract

Epstein Barr virus-associated smooth muscle tumors are an uncommon neoplasm that occurs in immunosuppressed patients of any age. Usually, it presents as multifocal tumors mainly in the spinal cord, epidural region, gastrointestinal tract and liver, upper respiratory tract and skin, the latest with few cases reported in the literature and related with human immunodeficiency virus infection and acquired immune deficiency syndrome. The authors present the first case of a Colombian adult patient with human immunodeficiency virus infection and multifocal Epstein Barr virus-associated smooth muscle tumors in the skin and epidural region, confirmed by histopathology, immunohistochemistry and in situ hybridization studies.

Keywords: Epstein-Barr virus infections; HIV; Skin manifestations; Smooth muscle tumor.

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Figures

Figure 1
Figure 1
Linear subcutaneous nodule on the dorsum of the right hand.
Figure 2
Figure 2
Nuclear magnetic resonance of the spine with epidural infiltration and foraminal involvement of T11 and T12, with compression and displacement of the spinal cord.
Figure 3
Figure 3
Subcutaneous nodule. (A and B), well circumscribed nodular formation formed by spindle cell bundles with minimal atypia and few mitotic figures (Hematoxylin & eosin ×100 and ×400, respectively). (C and D), SMA and H-caldesmon positive immunohistochemistry, respectively.
Figure 4
Figure 4
Epidural lesion. (A and B), confused lesion by spindle cell bundles with low atypia (Hematoxylin & eosin ×100 and ×400, respectively). (C and D), SMA and H-caldesmon positive immunohistochemistry, respectively.
Figure 5
Figure 5
In situ hybridization study for detection of Epstein-Barr virus.
See this image and copyright information in PMC

References

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