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Randomized Controlled Trial
. 2021 Jul;106(4):398-403.
doi: 10.1136/archdischild-2020-320241. Epub 2021 Feb 24.

Hypotension in Preterm Infants (HIP) randomised trial

Eugene M Dempsey  1 , Keith J Barrington  2 , Neil Marlow  3 , Colm Patrick Finbarr O'Donnell  4 , Jan Miletin  5 , Gunnar Naulaers  6 , Po-Yin Cheung  7 , John David Corcoran  8 , Afif Faisal El-Khuffash  8 , Geraldine B Boylan  9 , Vicki Livingstone  9 , Gerard Pons  10 , Jozef Macko  11 , David Van Laere  12 , Hana Wiedermannova  13 , Zbyněk Straňák  14 ; HIP consortium
Affiliations
Randomized Controlled Trial

Hypotension in Preterm Infants (HIP) randomised trial

Eugene M Dempsey et al. Arch Dis Child Fetal Neonatal Ed. 2021 Jul.

Abstract

Objective: To determine whether restricting the use of inotrope after diagnosis of low blood pressure (BP) in the first 72 hours of life affects survival without significant brain injury at 36 weeks of postmenstrual age (PMA) in infants born before 28 weeks of gestation.

Design: Double-blind, placebo-controlled randomised trial. Caregivers were masked to group assignment.

Setting: 10 sites across Europe and Canada.

Participants: Infants born before 28 weeks of gestation were eligible if they had an invasive mean BP less than their gestational age that persisted for ≥15 min in the first 72 hours of life and a cerebral ultrasound free of significant (≥ grade 3) intraventricular haemorrhage.

Intervention: Participants were randomly assigned to saline bolus followed by either a dopamine infusion (standard management) or placebo (5% dextrose) infusion (restrictive management).

Primary outcome: Survival to 36 weeks of PMA without severe brain injury.

Results: The trial terminated early due to significant enrolment issues (7.7% of planned recruitment). 58 infants were enrolled between February 2015 and September 2017. The two groups were well matched for baseline variables. In the standard group, 18/29 (62%) achieved the primary outcome compared with 20/29 (69%) in the restrictive group (p=0.58). Additional treatments for low BP were used less frequently in the standard arm (11/29 (38%) vs 19/29 (66%), p=0.038).

Conclusion: Though this study lacked power, we did not detect major differences in clinical outcomes between standard or restrictive approach to treatment. These results will inform future studies in this area.

Trial registration number: NCT01482559, EudraCT 2010-023988-17.

Keywords: cardiology; neonatology; pharmacology.

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Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
Trial design flow diagram. BP, blood pressure; GA, gestational age.
Figure 2
Figure 2
CONSORT diagram. CONSORT, Consolidated Standards of Reporting Trials.
Figure 3
Figure 3
Changes in MBP over time by group. MBP, mean blood pressure.
See this image and copyright information in PMC

Comment in

References

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