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Review
. 2021 Feb 4:2021:8884283.
doi: 10.1155/2021/8884283. eCollection 2021.

Myogenic Differentiation of Stem Cells for Skeletal Muscle Regeneration

Dengjie Yu  1   2 , Zijun Cai  1   2 , Daishi Li  3 , Yi Zhang  1   2 , Miao He  1   2 , Yuntao Yang  1   2 , Di Liu  1   2 , Wenqing Xie  1   2 , Yusheng Li  1   2 , Wenfeng Xiao  1   2
Affiliations
Review

Myogenic Differentiation of Stem Cells for Skeletal Muscle Regeneration

Dengjie Yu et al. Stem Cells Int. .

Abstract

Stem cells have become a hot research topic in the field of regenerative medicine due to their self-renewal and differentiation capabilities. Skeletal muscle tissue is one of the most important tissues in the human body, and it is difficult to recover when severely damaged. However, conventional treatment methods can cause great pain to patients. Stem cell-based tissue engineering can repair skeletal muscle to the greatest extent with little damage. Therefore, the application of stem cells to skeletal muscle regeneration is very promising. In this review, we discuss scaffolds and stem cells for skeletal muscle regeneration and put forward our ideas for future development.

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Conflict of interest statement

The authors declare that there is no conflict of interest regarding the publication of this paper.

Figures

Figure 1
Figure 1
Schematic diagram of muscle regeneration. Skeletal muscle tissue regeneration is regulated by a genetic cascade involving Pax7 and MRFs, which drive every step of satellite cell activation, transient expansion of progenitor cells, and the differentiation and formation of new muscle fibers. Interestingly, satellite cell self-renewal can retain a small number of rested cells after regeneration to meet future regeneration needs.
Figure 2
Figure 2
Schematic diagram of the general process of skeletal muscle tissue engineering. Taking the method of treating the biceps brachii defect with porous scaffolds as an example. First, seed cells are obtained from the biceps brachii on the healthy arm and are cultured in vitro. Next, we should make seed cells attached to porous scaffolds and add growth factors. Finally, a small amount of healthy skeletal muscle tissue is obtained and then implanted into the human body.
See this image and copyright information in PMC

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