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Review
. 2021 Feb 4:2021:8852759.
doi: 10.1155/2021/8852759. eCollection 2021.

The Role of Oxidative Stress and Antioxidants in Diabetic Wound Healing

Liling Deng  1 , Chenzhen Du  1 , Peiyang Song  1 , Tianyi Chen  1 , Shunli Rui  1 , David G Armstrong  2 , Wuquan Deng  1
Affiliations
Review

The Role of Oxidative Stress and Antioxidants in Diabetic Wound Healing

Liling Deng et al. Oxid Med Cell Longev. .

Abstract

Foot ulcers are one of the most common and severe complication of diabetes mellitus with significant resultant morbidity and mortality. Multiple factors impair wound healing include skin injury, diabetic neuropathy, ischemia, infection, inadequate glycemic control, poor nutritional status, and severe morbidity. It is currently believed that oxidative stress plays a vital role in diabetic wound healing. An imbalance of free radicals and antioxidants in the body results in overproduction of reactive oxygen species which lead to cell, tissue damage, and delayed wound healing. Therefore, decreasing ROS levels through antioxidative systems may reduce oxidative stress-induced damage to improve healing. In this context, we provide an update on the role of oxidative stress and antioxidants in diabetic wound healing through following four perspectives. We then discuss several therapeutic strategies especially dietary bioactive compounds by targeting oxidative stress to improve wounds healing.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
The role of oxidative stress in development and chronicity of diabetic wound.
Figure 2
Figure 2
The main pathways with oxidative stress in diabetic neuropathy.
See this image and copyright information in PMC

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