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Case Reports
. 2021 Feb 11:9:2050313X20979560.
doi: 10.1177/2050313X20979560. eCollection 2021.

Palisaded neutrophilic and granulomatous dermatitis following a long-standing monoclonal gammopathy: A case report

Dorsa Zabihi-Pour  1 , Bahar Bahrani  2 , Dalal Assaad  2 , Jensen Yeung  3
Affiliations
Case Reports

Palisaded neutrophilic and granulomatous dermatitis following a long-standing monoclonal gammopathy: A case report

Dorsa Zabihi-Pour et al. SAGE Open Med Case Rep. .

Abstract

Background: Palisaded neutrophilic granulomatous dermatitis is a rare inflammatory dermatosis with possible underlying systemic conditions including rheumatoid arthritis, autoimmune connective tissue disease, and malignancies.

Case summary: We report a case of an 84-year-old man presenting with a 3-week eruption of asymptomatic annular plaques on his neck, which progressed to involve his back and legs. Skin biopsies confirmed a diagnosis of palisaded neutrophilic granulomatous dermatitis, and he was treated with prednisone. Full workup related to potential underlying causes of palisaded neutrophilic granulomatous dermatitis was completed.

Conclusion: Palisaded neutrophilic granulomatous dermatitis may precede the onset of underlying systemic conditions or occur concomitantly. Following the diagnosis, clinicians should perform a comprehensive focused history, physical examination, and laboratory investigation related to the associated underlying diseases.

Keywords: Palisaded neutrophilic and granulomatous dermatitis; dermatoses with underlying systemic conditions; neutrophilic dermatoses.

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Conflict of interest statement

Declaration of conflicting interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Palisaded neutrophilic and granulomatous dermatitis clinical presentation and biopsy: (a) clinical image and distribution of plaques. (b) Punch biopsy specimen with a mixture of lymphocytic and neutrophilic infiltrates around the vessel and scattered interstitially. Also, focal histiocytes observed between collagen bundles. (b) Hematoxylin–eosin stain; original magnification: ×100.
See this image and copyright information in PMC

References

    1. Sangueza OP, Caudell MD, Mengesha YM, et al. Palisaded neutrophilic granulomatous dermatitis in rheumatoid arthritis. J Am Acad Dermatol 2002; 3: 425–428. - PubMed
    1. Kyriakou A, Patsatsi A, Papadopoulos V, et al. A case of palisaded neutrophilic granulomatous dermatitis with subsequent development of chronic myelomonocytic leukemia. Clin Case Rep 2019; 7(4): 695–698. - PMC - PubMed
    1. Shenk MER, Ken KM, Braudis K, et al. Palisaded neutrophilic and granulomatous dermatitis associated with ledipasvir/sofosbuvir. JAAD Case Rep 2018; 4(8): 808–810. - PMC - PubMed
    1. Kwon EJ, Hivnor CM, Yan AC, et al. Interstitial granulomatous lesions as part of the spectrum of presenting cutaneous signs in pediatric sarcoidosis. Pediatr Dermatol 2007; 24(5): 517–524. - PubMed
    1. Gordon K, Miteva M, Torchia D, et al. Allopurinol-induced palisaded neutrophilic and granulomatous dermatitis. Cutan Ocul Toxicol 2012; 31(4): 338–340. - PubMed

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