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Case Reports
. 2021 Jan 20;13(1):e12816.
doi: 10.7759/cureus.12816.

Gastric Splenosis Mimicking Gastrointestinal Stromal Tumor

Gowthami Kanagalingam  1 , Vrinda Vyas  1 , Vanessa Sostre  2 , Muhammad Osman Arif  2
Affiliations
Case Reports

Gastric Splenosis Mimicking Gastrointestinal Stromal Tumor

Gowthami Kanagalingam et al. Cureus. .

Abstract

Translocation of splenic tissue in patients after traumatic spleen injury or splenectomy is called splenosis. Gastric splenosis is a rare presentation that can be mistaken for gastrointestinal stromal tumor (GIST). Patients are usually asymptomatic and do not require surgical intervention. In this report, we present a case of a 68-year-old male patient with a previous history of surgical splenectomy after traumatic splenic rupture, who underwent routine upper endoscopy for the evaluation of dysphagia. An endoscopic exam of the stomach revealed an incidental finding of a submucosal gastric nodule. On endoscopic ultrasound exam, the lesion was found to be suggestive of GIST originating from layer 4. A core biopsy was obtained from the nodule, which was consistent with gastric splenosis. The differentiation of gastric splenosis from other gastric lesions such as GIST is important since asymptomatic patients with gastric splenosis do not need to undergo surveillance or surgical resection. It should be suspected especially in patients with a history of splenectomy or splenic rupture. Endoscopic ultrasound (EUS)-guided core biopsy can help confirm the diagnosis and differentiate the condition from GIST.

Keywords: endoscopic ultrasound (eus); gastrointestinal stromal tumor (gist); splenic trauma.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Submucosal papule in the fundus of the stomach
Figure 2
Figure 2. Submucosal papule that appears to be originating from within muscularis propria, layer 4
Figure 3
Figure 3. Core biopsy of the lesion showing multiple soft tan-white tissue cores composed of blood and eosinophilic stroma with eosinophils, macrophages, plasma cells, and neutrophils consistent with gastric splenosis
See this image and copyright information in PMC

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