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Case Reports
. 2021 Jan 22;13(1):e12850.
doi: 10.7759/cureus.12850.

Indeterminate Cell Histiocytosis Mimicking Rosacea

Andrew S Fischer  1 , Angela G Zaladonis  2 , Paul Subrt  3 , Jaime Tschen  4 , Sylvia Hsu  2
Affiliations
Case Reports

Indeterminate Cell Histiocytosis Mimicking Rosacea

Andrew S Fischer et al. Cureus. .

Abstract

Indeterminate cell histiocytosis (ICH) is a rare proliferative disorder of histiocytes, which display morphologic and immunophenotypic characteristics of both Langerhans cell histiocytosis (LCH) and non-Langerhans cell histiocytosis (NLCH). We describe an unusual clinical presentation of ICH mimicking rosacea and provide a relevant review of the literature.

Keywords: ich; indeterminate cell histiocytosis; rosacea.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Clinical photograph of the face at the time of presentation to our clinic, showing extensive erythematous papules on the face and anterior neck.
Figure 2
Figure 2. H&E photomicrograph at low power, showing a nodular infiltrate in the upper dermis.
Figure 3
Figure 3. H&E photomicrograph, high power, showing mononuclear infiltrate.
Figure 4
Figure 4. Photomicrograph of CD68 immunostain, showing scattered positivity.
Figure 5
Figure 5. Photomicrograph of Langerin immunostain, showing lack of expression within the infiltrate.
Figure 6
Figure 6. Clinical photograph of the face at six month follow-up, showing progression to thickened plaques.
Figure 7
Figure 7. Clinical photograph of the upper arm at six month follow-up, showing progression beyond the head and neck.
See this image and copyright information in PMC

References

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