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Review
. 2021 Feb 8:11:570241.
doi: 10.3389/fonc.2021.570241. eCollection 2021.

Immune Microenvironment: New Insight for Familial Adenomatous Polyposis

Jun Yang  1 , Zhengqi Wen  1 , Wenliang Li  1 , Xianghua Sun  2 , Junrui Ma  3 , Xueke She  4 , Hongbin Zhang  1 , Changling Tu  5 , Guoqiang Wang  4 , Depei Huang  4 , Xudong Shen  4 , Jian Dong  5 , Hushan Zhang  4
Affiliations
Review

Immune Microenvironment: New Insight for Familial Adenomatous Polyposis

Jun Yang et al. Front Oncol. .

Abstract

Currently, the main treatment for familial adenomatous polyposis (FAP) is surgery, however, surgery is far from ideal as there are many complications such as uncontrollable bowel movements, pouch inflammation, anastomotic stricture, and secondary fibroids. Therefore, it is necessary to further expand the understanding of FAP and develop new treatments for FAP. The immune microenvironment including immune cells and cytokines, plays an important role in FAP and the progression of FAP to adenocarcinoma, thus it may be a promising treatment for FAP. In the current review, we summarized the recent progress in the immune microenvironment of FAP.

Keywords: FAP; colorectal cancer; cytokines; immune cells; immune microenvironment.

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Conflict of interest statement

Authors HSZ, XKS, GW, XS, and DH are employed by the company 3D Medicines Inc. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
The changes of T cell subsets during FAP progress from polyp to adenoma and to adenocarcinoma.
Figure 2
Figure 2
The role and the polarization of tumor-associated macrophages during FAP progress from polyp to adenoma and to adenocarcinoma.
Figure 3
Figure 3
The role of various cytokines involved in the progression of FAP disease.
See this image and copyright information in PMC

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