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Meta-Analysis
. 2021 Feb 4:2021:5304124.
doi: 10.1155/2021/5304124. eCollection 2021.

Diabetic Peripheral Neuropathy in Ethiopia: A Systematic Review and Meta-Analysis

Degena Bahrey Tadesse  1 , Gebremeskel Tukue Gebrewahd  2 , Abrha Hailay  1 , Woldu Aberhe  1 , Guesh Mebrahtom  1 , Kidane Zereabruk  1 , Guesh Gebreayezgi  3 , Teklewoini Mariye  1 , Teklehaimanot Gereziher Haile  4 , Gebreamlak Gebremedhn Gebremeskel  1 , Gebre Teklemariam Demoz  5
Affiliations
Meta-Analysis

Diabetic Peripheral Neuropathy in Ethiopia: A Systematic Review and Meta-Analysis

Degena Bahrey Tadesse et al. J Diabetes Res. .

Abstract

Background: Currently, diabetic peripheral neuropathy (DPN) is one of the most severe complications of diabetes mellitus (DM). Despite the seriousness of this problem, limited evidence is available on the prevalence of diabetic peripheral neuropathy among patients with diabetes mellitus in Ethiopia. In Ethiopia, there were no updated studies that estimate the national prevalence of DPN. Hence, this systematic review and meta-analysis provided a national prevalence of diabetic peripheral neuropathy among patients with diabetes mellitus in Ethiopia.

Methods: This study was submitted for registration with the International Prospective Register of Systematic Reviews (PROSPERO) in March 2020 and accepted with the registration number CRD42020173831. Different database searching engines were searched online to retrieve related articles, including PubMed, Scopus, Google Scholar, African Journals Online, World Health Organization (WHO) Afro Library, and Cochrane Review. The reviewers used the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guideline in the reviewing process. In this systematic review and meta-analysis, all published and unpublished articles were analyzed. The reviewers used the random effects model to estimate the pooled prevalence of diabetic peripheral neuropathy among diabetes mellitus patients. The reviewers conducted the statistical analysis using the R version 3.5.3 and RStudio version 1.2.5033 software for Windows. The reviewers evaluated the heterogeneity across the included studies by the inconsistency index (I 2). The reviewers examined the publication bias by the funnel plot.

Results: The search of the databases produced 245 papers. After checking the inclusion and exclusion criteria, 38 articles with 14029 total patients with diabetes mellitus were found suitable for the review. Except for three (retrospective cohort study), all studies were cross-sectional. The overall pooled prevalence of diabetic peripheral neuropathy was 22% (95% CI 18% to 26%). The subgroup analysis of diabetic peripheral neuropathy among patients with diabetes in the different regions was 23% (95% CI 17% to 29%) in Addis Ababa, 27% (95% CI 16% to 38%) in Oromia, 16% (95% CI 14% to 18%) in South nation and nationalities, and 15% (95% CI 6% to 24%) in Amhara.

Conclusions: More than one-fifth of patients with diabetes have diabetic peripheral neuropathy. According to this study, the prevalence of diabetic peripheral neuropathy in Ethiopia is considerably high. This evidence suggests that attention should be given to patients with diabetes in monitoring patients' blood glucose.

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Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
Flow chart diagram showing the selection of articles for systemic review and meta-analysis of DPN among patients with diabetes in Ethiopia, 2020.
Figure 2
Figure 2
Forest plot for the pooled prevalence of DPN from 38 observational studies.
Figure 3
Figure 3
Funnel plot showing evidence of publication bias across studies.
Figure 4
Figure 4
Forest plot of DPN in Addis Ababa.
Figure 5
Figure 5
Forest plot of DPN in the Oromia region.
Figure 6
Figure 6
Forest plot of DPN in the south region.
Figure 7
Figure 7
Forest plot of DPN in the Amhara region.
See this image and copyright information in PMC

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