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Comment
. 2021 Feb 25;137(8):1006-1007.
doi: 10.1182/blood.2020010459.

Another front in COVID-19's perfect storm

Shawn M Jobe  1   2 , Renren Wen  1
Affiliations
Comment

Another front in COVID-19's perfect storm

Shawn M Jobe et al. Blood. .

Abstract

In this issue of Blood, Althaus et al identify circulating procoagulant platelets as a novel biomarker of COVID-19 disease severity and present provocative in vitro findings demonstrating that antibodies induced in response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can initiate procoagulant platelet formation.

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Conflict of interest statement

Conflict-of-interest disclosure: The authors declare no competing financial interests.

Conflict-of-interest disclosure: The authors declare no competing financial interests.

Comment on

  • Antibody-induced procoagulant platelets in severe COVID-19 infection.
    Althaus K, Marini I, Zlamal J, Pelzl L, Singh A, Häberle H, Mehrländer M, Hammer S, Schulze H, Bitzer M, Malek N, Rath D, Bösmüller H, Nieswandt B, Gawaz M, Bakchoul T, Rosenberger P. Althaus K, et al. Blood. 2021 Feb 25;137(8):1061-1071. doi: 10.1182/blood.2020008762. Blood. 2021. PMID: 33512415 Free PMC article.

References

    1. Althaus K, Marini I, Zlamal J, et al. . Antibody-induced procoagulant platelets in severe COVID-19 infection. Blood. 2021;137(8):1061-1071. - PMC - PubMed
    1. Wool GD, Miller JL. The impact of COVID-19 disease on platelets and coagulation. Pathobiology. 2021;88(1):15-27. - PMC - PubMed
    1. Dale GL. Procoagulant platelets: further details but many more questions. Arterioscler Thromb Vasc Biol. 2017;37(9):1596-1597. - PubMed
    1. Denorme F, Manne BK, Portier I, et al. . Platelet necrosis mediates ischemic stroke outcome in mice. Blood. 2020;135(6):429-440. - PMC - PubMed
    1. Yuan Y, Alwis I, Wu MCL, et al. . Neutrophil macroaggregates promote widespread pulmonary thrombosis after gut ischemia. Sci Transl Med. 2017;9(409):eaam5861. - PubMed