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. 2021 Jun 1;46(6):e327-e328.
doi: 10.1097/RLU.0000000000003547.

FDG PET Unveils the Course of Paraneoplastic Cerebellar Degeneration: A Semiquantitative Analysis

Federico Massa  1 , Laura Filippi  1 , Luana Benedetti, Silvia Morbelli  2 , Flavio Nobili
Affiliations

FDG PET Unveils the Course of Paraneoplastic Cerebellar Degeneration: A Semiquantitative Analysis

Federico Massa et al. Clin Nucl Med. .

Abstract

In paraneoplastic cerebellar degeneration (PCD), the standard diagnostic workup might be inconclusive, especially in seronegative subtypes. Brain 18F-FDG PET is an accurate supportive diagnostic tool in immune-mediated disorders, but findings in PCD are controversial. Semiquantitative analysis of 18F-FDG PET can meaningfully assist visual assessment in different neurological conditions and has been mainly applied to disclose regional hypometabolism. We describe a seronegative PCD associated with small cell lung cancer in which 18F-FDG PET semiquantitative analysis accurately disclosed the longitudinal pathological changes of brain metabolism occurring in the acute and posttreatment remission stages and paralleling clinical impairment and response to treatment.

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Conflict of interest statement

Conflicts of interest and sources of funding: S.M. has received speaker honoraria from GE Healthcare. F.N. has received fees for participating in boards from Roche, and speaker honoraria from Bial e G.E. Healthcare. The other authors have nothing to disclose.

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