A Systematic Review of Procedural Complications from Transforaminal Lumbar Puncture for Intrathecal Nusinersen Administration in Patients with Spinal Muscular Atrophy

Abstract

Background: Spinal muscular atrophy is a progressive neurodegenerative disorder that can be treated with intrathecal antisense oligonucleotide therapy (nusinersen). However, administration is often complicated by posterior spinal fusion and neuromuscular scoliosis, necessitating a transforaminal approach.

Purpose: To assess the safety profile of the transforaminal approach for intrathecal access.

Data sources: Searches of the PubMed, Web of Science, and SCOPUS databases.

Study selection: Thirteen articles were selected based on inclusion of transforaminal access and appropriate clinical information about the procedure.

Data analysis: Complications were taken from the included articles and aggregated based on Cardiovascular and Interventional Radiological Society of Europe scale adverse event grading.

Data synthesis: Total number of complications and grade of complications were analyzed, by year and in total.

Limitations: Selection bias in publication, small patient population size, and variability of the procedure limits the available data.

Conclusions: Transforaminal approach is a safe alternative for intrathecal access in patients with spinal muscular atrophy and may be applicable to a larger patient population.

FIGURE.

Flowchart demonstrating the identification of eligible articles.