Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Feb 25;11(1):4716.
doi: 10.1038/s41598-021-83589-z.

The interaction on hypertension between family history and diabetes and other risk factors

An-le Li  1 , Qian Peng  2 , Yue-Qin Shao  2 , Xiang Fang  2 , Yi-Ying Zhang  2
Affiliations

The interaction on hypertension between family history and diabetes and other risk factors

An-le Li et al. Sci Rep. .

Abstract

To explore the individual effect and interaction of diabetes and family history and other risk factors on hypertension in Han in Shanghai China. The method of case-control study with l:l matched pairs was used, 342 cases of hypertension and 342 controls were selected and investigate their exposed factors with face-to-face. The method of epidemiology research was used to explore the individual effect and interaction of diabetes and family history and other risk factors on hypertension. The individual effect of family history (OR = 4.103, 95%CI 2.660-6.330), diabetes (OR = 4.219, 95%CI 2.926-6.083), personal taste (OR = 1.256, 95%CI 1.091-1.593), drinking behavior (OR = 1.391, 95%CI 1.010-1.914) and smoking behavior (OR = 1.057, 95%CI 1.00-1.117) were significant (p < 0.05). But individual effect of sex, education, occupation, work/life pressure, environmental noise, sleeping time and sports habit were not significant (p > 0.05). The OR of interaction between FH and DM to hypertension was 16.537 (95%CI 10.070-21.157), between FH and drinking behavior was 4.0 (95%CI 2.461-6.502), FH and sport habit was 7.668 (95%CI 3.598-16.344), FH and personal taste was 6.521 (95%CI 3.858-11.024), FH and smoking behavior was 5.526 (95%CI 3.404-8.972), FH and work/life pressure was 4.087 (95%CI 2.144-7.788). The SI of FH and DM was 2.27, RERI was 8.68, AP was 52.48% and PAP was 55.86%. FH and DM, personal taste, smoking behavior had positive interaction on hypertension, but FH and sport habits, drinking behavior, work/life pressure had reverse interaction on hypertension. FH and diabetes were very important risk factors with significant effect for hypertension. FH and diabetes, personal taste, smoking behavior had positive interaction on hypertension, but FH and sport habits, drinking behavior, work/life pressure had reverse interaction on hypertension.

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

References

    1. Li AL, Peng Q, Shao YQ, Fang X, Zhang YY. The effect of body mass index and its interaction with family history on hypertension: A case-control study. Clin. Hypertens. 2019;25(6):1–8. - PMC - PubMed
    1. Zaw KK, Latt TS, Aung PP, et al. Prevalence of hypertension and its associated factors in the adult population in Yangon Division, Myanmar. Asia Pac. J. Public Health. 2011;23(4):496–506. doi: 10.1177/1010539509349147. - DOI - PubMed
    1. Center for chronic non communicable diseases control and prevention of China Center for Disease Control and Prevention. Surveillance report of chronic diseases and their risk factors in China (2010) (Military Medical Science Press, Beijing, 2012).
    1. Ehrel GB. Genome-wide association studies: Contribution of genomic to understanding blood pressure and essential hypertension. Curr. Hypertens. Rep. 2010;12:17–25. doi: 10.1007/s11906-009-0086-6. - DOI - PMC - PubMed
    1. Li AL, Fang X, Zhang YY, Peng Q, Yin XH. Familial aggregation and heritability of hypertension in Han population in Shanghai China: A case-control study. Clin. Hypertens. 2019;25(17):1–7. - PMC - PubMed

Publication types