Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Feb 25;11(1):4522.
doi: 10.1038/s41598-021-83985-5.

Management of retinopathy of prematurity (ROP) in a Polish cohort of infants

Anna Chmielarz-Czarnocińska  1 , Marta Pawlak  2 , Dawid Szpecht  3 , Aneta Choręziak  2 , Marta Szymankiewicz-Bręborowicz  3 , Anna Gotz-Więckowska  2
Affiliations

Management of retinopathy of prematurity (ROP) in a Polish cohort of infants

Anna Chmielarz-Czarnocińska et al. Sci Rep. .

Abstract

Retinopathy of prematurity (ROP) is potentially blinding, but screening and timely treatment can stop its progression. The data on treatment outcomes of ROP from Central and Eastern Europe are scarce. Therefore, we aimed to analyze the latest results of ROP management in Poznan medical center to update the data from this world region. In the years 2016-2019, 178 patients (350 eyes) received treatment for ROP (6.1% of the screened population). The mean gestational age was 26 weeks (range 22-31 weeks), the mean birth weight was 868 g (range 410-1890 g). The most frequent ROP stage at treatment was zone II, stage 3 + (34.9%). As the first line of treatment, 115 infants (226 eyes, 64.6%) underwent laser photocoagulation (LP); 61 infants (120 eyes, 34.3%) received intravitreal ranibizumab injections (IVR); and 2 infants (4 eyes, 0.6%) were treated simultaneously with LP and IVR. One hundred twenty-six eyes (36%) of 63 patients required retreatment: 20.4% treated with LP and 66.7% treated with IVR. Retinal detachment occurred in 14 eyes (4%). The incidence of ROP, ROP requiring treatment, and reoccurrence rates are higher in the Polish population than in Western Europe and the USA. The identified treatment patterns find increasing use of anti-VEGF agents.

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Distribution of gestational age and birth weight among: (a) inborn; (b) outborn patients requiring treatment, in the years 2016–2019.
Figure 2
Figure 2
Distribution of treatment modalities for ROP patients in the years 2016–2019.
Figure 3
Figure 3
First-line treatment: (a) in inborn patients in the years 2016–2019; (b) in outborn patients in the years 2016–2019.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Terry TL. Extreme prematurity and fibroblastic overgrowth of persistent vascular sheath behind each crystalline lens from the Massachusetts Eye and Ear Infirmary. Am. J. Ophthalmol. 1942;25:203–204. doi: 10.1016/S0002-9394(42)92088-9. - DOI - PubMed
    1. Główny Urząd Statystyczny/Rocznik Demograficzny 2019 Demographic Yearbook 2019. Warsaw: Central Statistical Office (2019). https://stat.gov.pl/obszary-tematyczne/roczniki-statystyczne/roczniki-st... (Accessed 27 April 2020).
    1. Chan-Ling T, Gole GA, Quinn GE, Adamson SJ, Darlow BA. Pathophysiology, screening and treatment of ROP: A multi-disciplinary perspective. Prog. Retin. Eye Res. 2018;62:77–119. doi: 10.1016/j.preteyeres.2017.09.002. - DOI - PubMed
    1. Gotz-Więckowska A, Bakunowicz-Łazarczyk A, Hautz W, Filipek E, Niwald AM. Polish Ophthalmological Society revised guidelines for the management of retinopathy of prematurity. Klin. Oczna. 2020;2020:14–16. doi: 10.5114/ko.2020.94207. - DOI
    1. International Committee for the Classification of Retinopathy of Prematurity The International Classification of Retinopathy of Prematurity Revisited. Arch. Ophthalmol. 2005;123:991. doi: 10.1001/archopht.123.7.991. - DOI - PubMed

MeSH terms