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Review
. 2020 Jun 19;10(1):14-21.
doi: 10.1097/XCE.0000000000000214. eCollection 2021 Mar.

The epidemiological status, environmental and genetic factors in the etiology of Keshan disease

Chao Yan  1 , Rong Luo  2 , Feng Li  3 , Mingjiang Liu  4 , Jinshu Li  3 , Wei Hua  4 , Xiaoping Li  1   2   4
Affiliations
Review

The epidemiological status, environmental and genetic factors in the etiology of Keshan disease

Chao Yan et al. Cardiovasc Endocrinol Metab. .

Abstract

Keshan disease (KD) is an endemic cardiomyopathy with myocardial lesions for which the precise etiology has not been determined. It was named after the location where it was first identified: Keshan County in China. KD is mainly distributed in a selenium-deficient zone from northeast to southwest China. In recent years, the incidence and prevalence of KD have significantly decreased. Meanwhile, more knowledge was accumulated about the etiology of KD and recent data indicated that genetic factor was involved. In this review, we will first update an overview of the epidemiological status and the environmental and genetic factors involved in this disease.

Keywords: Keshan disease; epidemiology; genetics.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Fig. 1
Fig. 1
The national detection and incidence rate of Keshan disease (KD) in China from 1990 to 2009. (a) The plot showed the trends of the national detection rates of KD, latent KD and chronic KD during 1990–2009. (b) The plot showed the trends of the national incidence rates of KD, latent KD and chronic KD during 1990–2009.
Fig. 2
Fig. 2
The detection rates of Keshan disease (KD) of the seven provinces in China during 2010–2016.
See this image and copyright information in PMC

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