Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Aug;23(8):1497-1510.
doi: 10.1007/s12094-021-02552-6. Epub 2021 Feb 25.

Complex roles of discoidin domain receptor tyrosine kinases in cancer

V Mehta  1 , H Chander  2   3 , A Munshi  2
Affiliations
Review

Complex roles of discoidin domain receptor tyrosine kinases in cancer

V Mehta et al. Clin Transl Oncol. 2021 Aug.

Abstract

Discoidin domain receptors, DDR1 and DDR2 are members of the receptor tyrosine kinase (RTK) family that serves as a non-integrin collagen receptor and were initially identified as critical regulators of embryonic development and cellular homeostasis. In recent years, numerous studies have focused on the role of these receptors in disease development, in particular, cancer where they have been reported to augment ECM remodeling, invasion, drug resistance to facilitate tumor progression and metastasis. Interestingly, accumulating evidence also suggests that DDRs promote apoptosis and suppress tumor progression in various human cancers due to which their functions in cancer remain ill-defined and presents a case of an interesting therapeutic target. The present review has discussed the role of DDRs in tumorigenesis and the metastasis.

Keywords: Cancer cell signalling; Collagen; Discoidin domain receptor; Invasion; Metastasis; Receptor tyrosine kinase.

PubMed Disclaimer

References

    1. Lemmon MA, Schlessinger J. Cell signaling by receptor tyrosine kinases. Cell. 2010;141(7):1117–34. https://doi.org/10.1016/j.cell.2010.06.011 . - DOI - PubMed - PMC
    1. Leitinger B. Discoidin domain receptor functions in physiological and pathological conditions. Int Rev Cell Mol Biol. 2014;310:39–87. - DOI
    1. El Azreq M-A, Kadiri M, Boisvert M, Pagé N, Tessier PA, Aoudjit F. Discoidin domain receptor 1 promotes Th17 cell migration by activating the RhoA/ROCK/MAPK/ERK signaling pathway. Oncotarget. 2016;7(29):44975. - DOI
    1. Vogel W, Gish GD, Alves F, Pawson T. The discoidin domain receptor tyrosine kinases are activated by collagen. Mol Cell. 1997;1(1):13–23. https://doi.org/10.1016/s1097-2765(00)80003-9 . - DOI - PubMed
    1. Shrivastava A, Radziejewski C, Campbell E, Kovac L, McGlynn M, Ryan TE, et al. An orphan receptor tyrosine kinase family whose members serve as nonintegrin collagen receptors. Mol Cell. 1997;1(1):25–34. https://doi.org/10.1016/S1097-2765(00)80004-0 . - DOI - PubMed

LinkOut - more resources