Altered leukocyte rheology in patients with chronic cerebrovascular disease

Abstract

Erythrocyte and leukocyte suspensions were prepared from 28 patients with chronic cerebrovascular disease and 30 age- and concomitant disease-matched control subjects. Cell filterability was studied with the new St. George's filtrometer, which can discriminate between initial filtration rate as an erythrocyte parameter and filter clogging as a leukocyte parameter. Compared with control subjects, a significant increase of filter clogging was found in the patients, suggesting decreased deformability or increased adhesiveness of leukocytes or both in chronic cerebrovascular disease.