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. 2021 May 15:40:127879.
doi: 10.1016/j.bmcl.2021.127879. Epub 2021 Feb 24.

1,2,3-Triazole-gold(I)-triethylposphine derivatives active against resistant Gram-positive pathogens

Mathieu Michaut  1 , Alexandre Steffen  1 , Jean-Marie Contreras  1 , Christophe Morice  1 , Isabelle J Schalk  2 , Patrick Plésiat  3 , Gaëtan L A Mislin  4
Affiliations

1,2,3-Triazole-gold(I)-triethylposphine derivatives active against resistant Gram-positive pathogens

Mathieu Michaut et al. Bioorg Med Chem Lett. .

Abstract

Innovative organogold(I) antibacterial compounds were synthesized by click chemistry with triethylphosphine-gold(I) azides and an alkyne derivative. The resulting organo-gold(I) compounds exhibit high levels of antibacterial activity against Gram-positive pathogens, with particularly low MICs against Clostridium difficile.

Keywords: Antibiotic; Azide-alkyne Huisgen cycloaddition; Clostridium difficile; Enterococcus sp.; Gold(I) complex; Staphylococcus sp..

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