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Comment
. 2021 Mar;99(3):537-539.
doi: 10.1016/j.kint.2020.10.045.

Rhabdomyolysis and complement-once again, epithelial cells take center stage

Joshua M Thurman  1
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Free article
Comment

Rhabdomyolysis and complement-once again, epithelial cells take center stage

Joshua M Thurman. Kidney Int. 2021 Mar.
Free article

Abstract

Rhabdomyolysis is frequently associated with kidney injury. Unfortunately, there are no specific treatments for this condition, and patient care primarily consists of supportive measures. In this edition of Kidney International, Boudhabhay et al. demonstrate that myoglobin released from injured skeletal muscle cells triggers tubulointerstitial complement activation. In a mouse model of the disease, interventions that scavenged free heme or that prevented complement activation ameliorated kidney injury, raising the possibility that these strategies may be effective treatments for the condition.

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  • Complement activation is a crucial driver of acute kidney injury in rhabdomyolysis.
    Boudhabhay I, Poillerat V, Grunenwald A, Torset C, Leon J, Daugan MV, Lucibello F, El Karoui K, Ydee A, Chauvet S, Girardie P, Sacks S, Farrar CA, Garred P, Berthaud R, Le Quintrec M, Rabant M, de Lonlay P, Rambaud C, Gnemmi V, Fremeaux-Bacchi V, Frimat M, Roumenina LT. Boudhabhay I, et al. Kidney Int. 2021 Mar;99(3):581-597. doi: 10.1016/j.kint.2020.09.033. Epub 2020 Nov 1. Kidney Int. 2021. PMID: 33137339

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