Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2021 Apr;42(4):275-277.
doi: 10.1016/j.it.2021.02.007. Epub 2021 Feb 23.

Liver Metastasis Irradiation Can Restore Immunotherapeutic Responsiveness

Sandra Demaria  1 , Silvia C Formenti  2
Affiliations
Comment

Liver Metastasis Irradiation Can Restore Immunotherapeutic Responsiveness

Sandra Demaria et al. Trends Immunol. 2021 Apr.

Abstract

Allogeneic liver transplants tolerize the immune system, preventing organ rejection from the same donor. A recent article by Yu et al. shows that liver metastases can likewise prevent tumor rejection in immunotherapy-treated murine and human hosts. Furthermore, radiation can reprogram the liver microenvironment to restore systemic tumor rejection.

PubMed Disclaimer

Conflict of interest statement

Declaration of Interests The authors declare that they have no competing interests related to this work. However, S.D. has received research support from Lytix Biopharma and consultant fees from Lytix Biopharma and Ono Pharmaceuticals. S.C.F. has received prior honorarium for consulting/speaker from AstraZeneca, Merck, Regeneron, Bayer, Serono, and research funding from Varian, Merck, Bristol Meyer Squibb.

Comment on

  • Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination.
    Yu J, Green MD, Li S, Sun Y, Journey SN, Choi JE, Rizvi SM, Qin A, Waninger JJ, Lang X, Chopra Z, El Naqa I, Zhou J, Bian Y, Jiang L, Tezel A, Skvarce J, Achar RK, Sitto M, Rosen BS, Su F, Narayanan SP, Cao X, Wei S, Szeliga W, Vatan L, Mayo C, Morgan MA, Schonewolf CA, Cuneo K, Kryczek I, Ma VT, Lao CD, Lawrence TS, Ramnath N, Wen F, Chinnaiyan AM, Cieslik M, Alva A, Zou W. Yu J, et al. Nat Med. 2021 Jan;27(1):152-164. doi: 10.1038/s41591-020-1131-x. Epub 2021 Jan 4. Nat Med. 2021. PMID: 33398162 Free PMC article.

Publication types

LinkOut - more resources