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Case Reports
. 2021 Feb 26;14(2):e241509.
doi: 10.1136/bcr-2020-241509.

Methotrexate encephalopathy presenting as choreoathetosis

Sanjeev Khera  1 , K P Shijith  2 , Jyotindra Narayan Goswami  3
Affiliations
Case Reports

Methotrexate encephalopathy presenting as choreoathetosis

Sanjeev Khera et al. BMJ Case Rep. .
No abstract available

Keywords: haematology (drugs and medicines); malignant and benign haematology; movement disorders (other than parkinsons); neurology (drugs and medicines).

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Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
T2-weighted coronal (A)and axial fluid-attenuated inversion recovery (B) images showing ill-defined, irregular, scattered areas of periventricular and deep white matter hyperintensities involving the bilateral cerebral hemispheres, predominantly the peritrigonal regions and the bilateral frontal lobes.
See this image and copyright information in PMC

References

    1. Howard SC, McCormick J, Pui C-H, et al. . Preventing and managing toxicities of high-dose methotrexate. Oncologist 2016;21:1471–82. 10.1634/theoncologist.2015-0164 - DOI - PMC - PubMed
    1. Inaba H, Khan RB, Laningham FH, et al. . Clinical and radiological characteristics of methotrexate-induced acute encephalopathy in pediatric patients with cancer. Ann Oncol 2008;19:178–84. 10.1093/annonc/mdm466 - DOI - PubMed
    1. Bhojwani D, Sabin ND, Pei D, et al. . Methotrexate-Induced neurotoxicity and leukoencephalopathy in childhood acute lymphoblastic leukemia. J Clin Oncol 2014;32:949–59. 10.1200/JCO.2013.53.0808 - DOI - PMC - PubMed

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