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Comment
. 2021 Feb 26;6(1):95.
doi: 10.1038/s41392-021-00523-5.

SARS-CoV-2 spike protein: a key target for eliciting persistent neutralizing antibodies

Yang Yang  1   2   3 , Lanying Du  4
Affiliations
Comment

SARS-CoV-2 spike protein: a key target for eliciting persistent neutralizing antibodies

Yang Yang et al. Signal Transduct Target Ther. .
No abstract available

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
SARS-CoV-2 spike (S) protein is a key target for eliciting neutralizing antibodies. a Schematic structures of SARS-CoV-2 virion and its S protein. M, membrane; E, envelope; N, nucleocapsid. Viral RNA is located inside the virion. NTD, N-terminal domain; RBD, receptor-binding domain; FP, fusion peptide; HR1 and HR2, heptad region 1 and 2; TM, transmembrane domain; IC, intracellular tail. b Mode of action of SARS-CoV-2 S-specific neutralizing antibodies. Monoclonal antibodies (mAbs) targeting S protein NTD prevent conformational changes of the S protein that are required for S2-mediated membrane fusion, and hence inhibit viral entry into host cells. RBD-targeting neutralizing mAbs or nanobodies (Nbs), on the other hand, bind directly to SARS-CoV-2 S protein RBD and compete with the cellular receptor, angiotensin converting enzyme 2 (ACE2), resulting in neutralization of viral infection and clearance of the virus. The following PDB entries are used for structural illustrations: 7C2L (structure of SARS-CoV-2 S in complex with NTD-targeting mAb 4A8), 7K4N (structure of SARS-CoV-2 S in complex with RBD-targeting mAb S2E12), 7KKK (structure of SARS-CoV-2 S in complex with RBD-targeting nanobody Nb6), and 6VW1 (structure of SARS-CoV-2 RBD in complex with human ACE2). SARS-CoV-2 S NTD is colored in orange, RBD in green, and the rest part of S protein in light blue. ACE2 is colored in purple. This figure was prepared using BioRender (https://biorender.com/) and UCSF ChimeraX (https://www.cgl.ucsf.edu/chimerax/)
See this image and copyright information in PMC

Comment on

  • Robust neutralizing antibodies to SARS-CoV-2 infection persist for months.
    Wajnberg A, Amanat F, Firpo A, Altman DR, Bailey MJ, Mansour M, McMahon M, Meade P, Mendu DR, Muellers K, Stadlbauer D, Stone K, Strohmeier S, Simon V, Aberg J, Reich DL, Krammer F, Cordon-Cardo C. Wajnberg A, et al. Science. 2020 Dec 4;370(6521):1227-1230. doi: 10.1126/science.abd7728. Epub 2020 Oct 28. Science. 2020. PMID: 33115920 Free PMC article.

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