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Comment
. 2021 Feb 26;6(1):96.
doi: 10.1038/s41392-021-00514-6.

Auto-antibodies against type I IFNs are associated with severe COVID-19 pneumonia

Weilin Zhou  1 , Wei Wang  2
Affiliations
Comment

Auto-antibodies against type I IFNs are associated with severe COVID-19 pneumonia

Weilin Zhou et al. Signal Transduct Target Ther. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Patients with life-threatening COVID-19 pneumonia caused by the SARS-CoV-2 virus produce auto-Abs (red) against type 1 IFNs.
See this image and copyright information in PMC

Comment on

  • Autoantibodies against type I IFNs in patients with life-threatening COVID-19.
    Bastard P, Rosen LB, Zhang Q, Michailidis E, Hoffmann HH, Zhang Y, Dorgham K, Philippot Q, Rosain J, Béziat V, Manry J, Shaw E, Haljasmägi L, Peterson P, Lorenzo L, Bizien L, Trouillet-Assant S, Dobbs K, de Jesus AA, Belot A, Kallaste A, Catherinot E, Tandjaoui-Lambiotte Y, Le Pen J, Kerner G, Bigio B, Seeleuthner Y, Yang R, Bolze A, Spaan AN, Delmonte OM, Abers MS, Aiuti A, Casari G, Lampasona V, Piemonti L, Ciceri F, Bilguvar K, Lifton RP, Vasse M, Smadja DM, Migaud M, Hadjadj J, Terrier B, Duffy D, Quintana-Murci L, van de Beek D, Roussel L, Vinh DC, Tangye SG, Haerynck F, Dalmau D, Martinez-Picado J, Brodin P, Nussenzweig MC, Boisson-Dupuis S, Rodríguez-Gallego C, Vogt G, Mogensen TH, Oler AJ, Gu J, Burbelo PD, Cohen JI, Biondi A, Bettini LR, D'Angio M, Bonfanti P, Rossignol P, Mayaux J, Rieux-Laucat F, Husebye ES, Fusco F, Ursini MV, Imberti L, Sottini A, Paghera S, Quiros-Roldan E, Rossi C, Castagnoli R, Montagna D, Licari A, Marseglia GL, Duval X, Ghosn J; HGID Lab; NIAID-USUHS Immune Response to COVID Group; COVID Clinicians; COVID-STORM Clinicians; Imagine COVID Group; French COVID Cohort Study Group; Milieu Intérieur Consortium; CoV-Contact Cohort; Amsterdam UMC Covid-19… See abstract for full author list ➔ Bastard P, et al. Science. 2020 Oct 23;370(6515):eabd4585. doi: 10.1126/science.abd4585. Epub 2020 Sep 24. Science. 2020. PMID: 32972996 Free PMC article.

References

    1. Bastard, P. et al. Auto-antibodies against type I IFNs in patients with life-threatening COVID-19. Science370 (2020). - PMC - PubMed
    1. Hadjadj J, et al. Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients. Science. 2020;369:718–724. doi: 10.1126/science.abc6027. - DOI - PMC - PubMed
    1. Zhang, Q. et al. Inborn errors of type I IFN immunity in patients with life-threatening COVID-19. Science370 (2020). - PMC - PubMed
    1. Casanova JL, Su HC. A global effort to define the human genetics of protective immunity to SARS-CoV-2 infection. Cell. 2020;181:1194–1199. doi: 10.1016/j.cell.2020.05.016. - DOI - PMC - PubMed
    1. Klein SL, et al. Sex, age, and hospitalization drive antibody responses in a COVID-19 convalescent plasma donor population. J. Clin. Investig. 2020;130:6141–1199. doi: 10.1172/JCI142004. - DOI - PMC - PubMed

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