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. 2021 Feb 26;11(1):4779.
doi: 10.1038/s41598-021-84079-y.

HPV genotyping and risk factors for anal high-risk HPV infection in men who have sex with men from Toronto, Canada

Yoojin Choi  1 , Mona Loutfy  2   3   4 , Robert S Remis  2 , Juan Liu  5 , Anuradha Rebbapragada  6 , Sanja Huibner  7 , Jason Brunetta  3 , Graham Smith  3 , Tatjana Reko  8 , Roberta Halpenny  3 , Rupert Kaul  9   7   10 , Troy Grennan  11   12   13
Affiliations

HPV genotyping and risk factors for anal high-risk HPV infection in men who have sex with men from Toronto, Canada

Yoojin Choi et al. Sci Rep. .

Abstract

Men who have sex with men (MSM) are disproportionately affected by anal cancer, predominantly caused by high-risk (HR) human papillomavirus (HPV) infection. Currently, the nonavalent HPV vaccine provides coverage against nine HPV genotypes, including seven HR-HPV genotypes. Here, we characterize anal HR-HPV genotype distribution and associated risk factors in MSM from Toronto, Canada recruited between September 2010 and June 2012. Wilcoxon-Mann-Whitney test was used for continuous variables, Chi-square test was performed for categorical variables, and a multivariable model using logistic regression was created to assess for correlates of anal HR-HPV infection. A total of 442 MSM were recruited, with a median age of 45 (IQR 38-50) and an overall HPV prevalence of 82%. The prevalence of any HR-HPV infection was 65.3% and 50.7% in the HIV-positive and HIV-negative MSM, respectively. No participant tested positive for all genotypes covered by the nonavalent vaccine. HIV status (aOR 1.806; 95% CI 1.159-2.816), smoking (aOR 2.176; 95% CI 1.285-3.685) and the number of lifetime sexual partners (aOR 2.466; 95% CI 1.092-5.567) were independent risk factors for anal HR-HPV infection. Our findings will be useful to inform HPV vaccine rollout and HPV prevention strategies in Canadian MSM.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Genotype-specific prevalence of anal HPV infection in the HIV-positive (n = 294) and HIV-negative participants (n = 148).
See this image and copyright information in PMC

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